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This study evaluated the NBIX effects in a model of gastric ulcer induced by EtOH in rats. Male Wistar rats received NBIX doses of 0, 10, and 25 mg\/kg by gavage 1 h after EtOH administration (0 or 75% solution, 1 mL\/200 g of animal). The animals were euthanized 1 h after the NBIX administration, and their stomachs were removed for macroscopic and histopathological analyses, quantification of nonprotein sulfhydryl (NPSH) groups, lipid peroxidation (LPO) levels, and catalase (CAT) activity determination. NBIX increased LPO in gastric mucosa and caused CAT inhibition and NPSH depletion in EtOH-treated animals. Results showed that NBIX did not protect gastric tissue against EtOH damage, and this could be associated to a prooxidant effect.<\/jats:p>","DOI":"10.1177\/0960327115604199","type":"journal-article","created":{"date-parts":[[2015,9,9]],"date-time":"2015-09-09T21:59:00Z","timestamp":1441835940000},"page":"737-746","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Prooxidant activity of norbixin in model of acute gastric ulcer induced by ethanol in rats"],"prefix":"10.1177","volume":"35","author":[{"given":"BT","family":"Rovani","sequence":"first","affiliation":[{"name":"Post-Graduate Program in Pharmaceutical Sciences, Federal University of Santa Maria, Santa Maria, Rio Grande do Sul, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RB","family":"de Freitas","sequence":"additional","affiliation":[{"name":"Post-Graduate Program in Pharmaceutical Sciences, Federal University of Santa 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