{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:40:23Z","timestamp":1777668023097,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2016,7,11]],"date-time":"2016-07-11T00:00:00Z","timestamp":1468195200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:p>In this study, we aimed to investigate disulfide\/thiol homeostasis in trichloroethylene (TCE) exposure. The study was carried out in 30 nonsmoker TCE-exposed workers with a variety of occupations. Additionally, 30 healthy nonsmoker volunteers were recruited as the control group. TCE exposure was determined by measuring urinary trichloroacetic acid (TCA) concentration. Median urinary TCA levels of exposed workers (20.5 mg\/L) were significantly higher than control subjects (5 mg\/L). Thiol and disulfide concentrations were determined using a novel automated method. Disulfide\/thiol ratio was significantly higher in the exposed group ( p &lt; 0.001). Thiol\/disulfide homeostasis was found to be disturbed in TCE-exposed workers. We predict that in TCE-exposed workers this disturbance can be a therapeutic target, and the efficiency of the treatment can easily be monitored by the novel method we used.<\/jats:p>","DOI":"10.1177\/0960327115608928","type":"journal-article","created":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T21:43:35Z","timestamp":1443735815000},"page":"915-920","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["The compromise of dynamic disulfide\/thiol homeostasis as a biomarker of oxidative stress in trichloroethylene exposure"],"prefix":"10.1177","volume":"35","author":[{"given":"C","family":"Bal","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Occupational Diseases Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"B\u00fcy\u00fck\u015fekerci","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Occupational Diseases Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Koca","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Atat\u00fcrk Educational and Research Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ER","family":"A\u011f\u0131\u015f","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Occupational Diseases Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Erdo\u011fan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Atat\u00fcrk Educational and Research Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Baran","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Atat\u00fcrk Educational and Research Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"G\u00fcnd\u00fcz\u00f6z","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Occupational Diseases Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6H","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Public Health, Y\u0131ld\u0131r\u0131m Beyaz\u0131t University, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,7,11]]},"reference":[{"key":"bibr1-0960327115608928","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70485-0"},{"key":"bibr2-0960327115608928","doi-asserted-by":"publisher","DOI":"10.2486\/indhealth.35.301"},{"key":"bibr3-0960327115608928","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2009.04.002"},{"key":"bibr4-0960327115608928","volume-title":"Toxicological Review of Trichloroethylene","author":"U.S. Environmental Protection Agency","year":"2011"},{"key":"bibr5-0960327115608928","doi-asserted-by":"publisher","DOI":"10.1080\/009841099158204"},{"key":"bibr6-0960327115608928","doi-asserted-by":"publisher","DOI":"10.1016\/S0962-8479(96)90069-6"},{"key":"bibr7-0960327115608928","doi-asserted-by":"publisher","DOI":"10.1080\/19338244.2013.763761"},{"key":"bibr8-0960327115608928","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2010.06.058"},{"key":"bibr9-0960327115608928","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2005.08.007"},{"key":"bibr10-0960327115608928","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(99)00083-9"},{"key":"bibr11-0960327115608928","doi-asserted-by":"publisher","DOI":"10.3390\/ijms16010193"},{"key":"bibr12-0960327115608928","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2013.09.026"},{"key":"bibr13-0960327115608928","doi-asserted-by":"publisher","DOI":"10.1007\/s13760-015-0427-y"},{"key":"bibr14-0960327115608928","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2009.12.022"},{"key":"bibr15-0960327115608928","doi-asserted-by":"publisher","DOI":"10.3109\/14017431.2015.1013153"},{"key":"bibr16-0960327115608928","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2014.09.026"},{"key":"bibr17-0960327115608928","volume-title":"Toxicolgical Profile for Trichloroethylene. Update Draft for Public Comments","author":"Agency for Toxic Substances and Disease Registry, Division of Toxicology","year":"2014"},{"key":"bibr18-0960327115608928","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0090-9556(24)14910-0","volume":"27","author":"Lash LH","year":"1999","journal-title":"Drug Metab Dispos"},{"key":"bibr19-0960327115608928","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-010-0540-x"},{"key":"bibr20-0960327115608928","volume-title":"Threshold Limit Values and Biological Exposure Indices","author":"American Conference of Governmental Industrial Hygienists","year":"2011"},{"key":"bibr21-0960327115608928","first-page":"551","volume":"41","author":"Cheng J","year":"2012","journal-title":"Wei Sheng Yan Jiu"},{"key":"bibr22-0960327115608928","doi-asserted-by":"publisher","DOI":"10.5539\/gjhs.v7n1p161"},{"key":"bibr23-0960327115608928","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-004-9683-6"},{"key":"bibr24-0960327115608928","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2005.08.007"},{"key":"bibr25-0960327115608928","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2008.01.002"},{"key":"bibr26-0960327115608928","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2015.01.102"},{"key":"bibr27-0960327115608928","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.100057"}],"container-title":["Human &amp; Experimental Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0960327115608928","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0960327115608928","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0960327115608928","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:48:39Z","timestamp":1777448919000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0960327115608928"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,11]]},"references-count":27,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1177\/0960327115608928"],"URL":"https:\/\/doi.org\/10.1177\/0960327115608928","relation":{},"ISSN":["0960-3271","1477-0903"],"issn-type":[{"value":"0960-3271","type":"print"},{"value":"1477-0903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,11]]}}}