{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T20:48:15Z","timestamp":1786826895065,"version":"build-2736575974"},"reference-count":45,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2016,7,11]],"date-time":"2016-07-11T00:00:00Z","timestamp":1468195200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:p>\n                    The present study was undertaken to evaluate the effect of diallylsulphide (DAS) against mercuric chloride (HgCl\n                    <jats:sub>2<\/jats:sub>\n                    )-induced oxidative stress in rat livers. Rats were randomly divided into four groups of six rats each and exposed to HgCl\n                    <jats:sub>2<\/jats:sub>\n                    (50 mg\/kg\/body weight (b.w.)) intraperitoneally and\/or DAS (200 mg\/kg\/b.w.) by gavage. HgCl\n                    <jats:sub>2<\/jats:sub>\n                    administration enhanced alanine aminotransferase (AST) and aspartate aminotransferase (ALT) levels ( p &lt; 0.05) with reduction in the levels of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px). However, treatment with DAS markedly attenuated HgCl\n                    <jats:sub>2<\/jats:sub>\n                    -induced biochemical alterations in liver and serum transaminases (AST and ALT; p &lt; 0.05). Further, biochemical results were confirmed by histopathological changes as compared to HgCl\n                    <jats:sub>2<\/jats:sub>\n                    -intoxicated rats. Histopathology of liver also showed that administration of DAS significantly reduced the damage generated by HgCl\n                    <jats:sub>2<\/jats:sub>\n                    . The present study suggests that DAS shows antioxidant activity and plays a protective role against mercury-induced oxidative damage in the rat livers.\n                  <\/jats:p>","DOI":"10.1177\/0960327116629723","type":"journal-article","created":{"date-parts":[[2016,1,29]],"date-time":"2016-01-29T20:53:51Z","timestamp":1454100831000},"page":"1305-1311","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Protective effect of diallylsulphide against mercuric chloride-induced hepatic injury in rats"],"prefix":"10.1177","volume":"35","author":[{"given":"S","family":"Ansar","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Sciences, College of Applied Medical Science, King Saud University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Iqbal","sequence":"additional","affiliation":[{"name":"Biotechnology Research Institute, 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