{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:58:16Z","timestamp":1791917896882,"version":"4.3.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2016,7,11]],"date-time":"2016-07-11T00:00:00Z","timestamp":1468195200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:p>Modulation of myometrial spontaneity by cadmium (Cd) and its regulatory pathways was studied in rat uterus in the absence and presence of blockers of different signaling pathways. Isometric tension in myometrial strips, under a resting tension of 1 g, mounted in organ bath containing Ringer\u2013Locke solution (RLS) continuously aerated with carbogen, was measured using data acquisition system-based physiograph and Lab Chart Pro V7.3.7 software. Mean integral tension was measured for 8 min. Cd (1 nM\u20130.1 mM) not only produced concentration-dependent inhibitory effect on rat myometrium but it (10 \u00b5M) also significantly ( p &lt; 0.05) inhibited calcium chloride and BAY K-8644-induced myometrial contraction. Glybenclamide (10 \u00b5M), 4-aminopyridine (1 mM), and propranolol (10 \u00b5M) failed to significantly attenuate Cd-induced inhibitory responses, while L-NAME (0.1 mM), 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one (ODQ; 25 \u00b5M), and 9-(tetrahydro-2-furanyl)-9H-purin-6-amine (SQ 22536; 1 \u00b5M) significantly ( p &lt; 0.05) produced inhibitory effects on Cd-induced myometrial relaxation. Phenylephrine (1 nM\u201310 \u00b5M) and salbutamol (0.01 nM\u20130.1 \u00b5M)-induced relaxant effects on rat myometrium were significantly potentiated by 10 \u00b5M Cd. Thus based on the results of present functional study, it may be inferred that inhibitory effects of Cd on rat myometrium are mediated through blockade of L-type calcium channels and activation of NOS-NO-sGC and\/or AC-cAMP pathways.<\/jats:p>","DOI":"10.1177\/0960327116646840","type":"journal-article","created":{"date-parts":[[2016,5,10]],"date-time":"2016-05-10T21:40:59Z","timestamp":1462916459000},"page":"276-286","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Functional involvement of L-type calcium channels and cyclic nucleotide-dependent pathways in cadmium-induced myometrial relaxation in rats"],"prefix":"10.1177","volume":"36","author":[{"given":"VK","family":"Saroj","sequence":"first","affiliation":[{"name":"Department of Pharmacology & Toxicology, Post Graduate Institute of Veterinary and Animal Sciences, Akola, MAFSU, Nagpur, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"UP","family":"Nakade","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pharmacology and Toxicology, Experimental Pharmacology Laboratory, College of Veterinary Science and Animal Husbandry, U.P. Pandit Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go-Anusandhan Sansthan, Mathura, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pharmacology and Toxicology, Experimental Pharmacology Laboratory, College of Veterinary Science and Animal Husbandry, U.P. Pandit Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go-Anusandhan Sansthan, Mathura, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RS","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pharmacology and Toxicology, Experimental Pharmacology Laboratory, College of Veterinary Science and Animal Husbandry, U.P. Pandit Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go-Anusandhan Sansthan, Mathura, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SW","family":"Hajare","sequence":"additional","affiliation":[{"name":"Department of Pharmacology & Toxicology, Post Graduate Institute of Veterinary and Animal Sciences, Akola, MAFSU, Nagpur, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SK","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pharmacology and Toxicology, Experimental Pharmacology Laboratory, College of Veterinary Science and Animal Husbandry, U.P. Pandit Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go-Anusandhan Sansthan, Mathura, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,7,11]]},"reference":[{"key":"bibr1-0960327116646840","unstructured":"ASTDR. ToxGuide\n                      TM\n                      for Cadmium, CAS# 7440-43-9. U.S. Department of Health and Human Services Public Health Service, Division of Toxicology and Human Health Sciences, Environmental Toxicology Branch, Atlanta, GA 30333 USA, 2012, p. 1. Available at: www.atsdr.cdc.gov\/toxguides\/toxguide-5.pdf"},{"key":"bibr2-0960327116646840","first-page":"17","volume":"3","author":"Sarkar A","year":"2013","journal-title":"Int J Biotechnol Res"},{"key":"bibr3-0960327116646840","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0092152"},{"key":"bibr4-0960327116646840","doi-asserted-by":"publisher","DOI":"10.1007\/s13181-011-0143-9"},{"key":"bibr5-0960327116646840","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2014.04.025"},{"key":"bibr6-0960327116646840","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.102.010785"},{"key":"bibr7-0960327116646840","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2010.05.003"},{"key":"bibr8-0960327116646840","doi-asserted-by":"publisher","DOI":"10.3109\/00016349509008914"},{"key":"bibr9-0960327116646840","first-page":"793","volume":"19","author":"Yildirim E","year":"2013","journal-title":"Kafkas Univ Vet Fak Derg"},{"key":"bibr10-0960327116646840","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1971.tb08046.x"},{"key":"bibr11-0960327116646840","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1982.tb09174.x"},{"key":"bibr12-0960327116646840","doi-asserted-by":"publisher","DOI":"10.2131\/jts.7.51"},{"key":"bibr13-0960327116646840","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(01)00355-9"},{"key":"bibr14-0960327116646840","doi-asserted-by":"publisher","DOI":"10.3109\/10641969909068674"},{"key":"bibr15-0960327116646840","doi-asserted-by":"publisher","DOI":"10.1007\/BF02898138"},{"key":"bibr16-0960327116646840","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)83208-2"},{"key":"bibr17-0960327116646840","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(89)82747-X"},{"key":"bibr18-0960327116646840","doi-asserted-by":"publisher","DOI":"10.1111\/and.12466"},{"key":"bibr19-0960327116646840","doi-asserted-by":"publisher","DOI":"10.1590\/S1519-69842002000400008"},{"key":"bibr20-0960327116646840","unstructured":"Ghosh MN. Anaesthetics used in laboratory animals, In Fundamentals of Experimental Pharmacology. 4th ed. Kolkata: Hilton & Company, 2008, pp. 19\u201323."},{"key":"bibr21-0960327116646840","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706644"},{"key":"bibr22-0960327116646840","doi-asserted-by":"publisher","DOI":"10.1080\/15287399109531558"},{"key":"bibr23-0960327116646840","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1977.tb16744.x"},{"key":"bibr24-0960327116646840","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)49259-9"},{"issue":"13","key":"bibr25-0960327116646840","first-page":"2671","volume":"2012","author":"Sadiq S","year":"2012","journal-title":"J Toxicol"},{"key":"bibr26-0960327116646840","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0031-6997(25)06663-3","volume":"43","author":"Moncada S","year":"1991","journal-title":"Pharmacol Rev"},{"key":"bibr27-0960327116646840","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.15.1.323"},{"key":"bibr28-0960327116646840","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod59.4.933"},{"key":"bibr29-0960327116646840","doi-asserted-by":"publisher","DOI":"10.1177\/107155769800500202"},{"key":"bibr30-0960327116646840","doi-asserted-by":"publisher","DOI":"10.1139\/O07-146"},{"key":"bibr31-0960327116646840","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2013.08.167"},{"key":"bibr32-0960327116646840","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2007.05.008"},{"key":"bibr33-0960327116646840","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-5-41"},{"key":"bibr34-0960327116646840","first-page":"795","volume":"43","author":"Mandi G","year":"2005","journal-title":"Indian J Exp Biol"},{"key":"bibr35-0960327116646840","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1993.1125"},{"key":"bibr36-0960327116646840","doi-asserted-by":"publisher","DOI":"10.1007\/BF00586350"},{"key":"bibr37-0960327116646840","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S0022-3565(25)23110-X","volume":"256","author":"Legrand C","year":"1991","journal-title":"J Pharmacol Exp Ther"},{"key":"bibr38-0960327116646840","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.00123.x"}],"container-title":["Human &amp; Experimental Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0960327116646840","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0960327116646840","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0960327116646840","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:48:57Z","timestamp":1777448937000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0960327116646840"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,11]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1177\/0960327116646840"],"URL":"https:\/\/doi.org\/10.1177\/0960327116646840","relation":{},"ISSN":["0960-3271","1477-0903"],"issn-type":[{"value":"0960-3271","type":"print"},{"value":"1477-0903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,11]]}}}