{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:51:53Z","timestamp":1787961113021,"version":"build-2784847793"},"reference-count":39,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2016,7,11]],"date-time":"2016-07-11T00:00:00Z","timestamp":1468195200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:p>\n                    In the present study, coumarin and some coumarin derivatives (esculetin, scoparone, and 4-methylumbelliferone) were investigated for their lipid-lowering effect in rats. Male Sprague\u2013Dawley rats (150\u2013200 g) were divided into six groups and each group comprised of five rats. Hepatic injury-dependent hyperlipidemia was induced by carbon tetrachloride (CCl\n                    <jats:sub>4<\/jats:sub>\n                    , 1.25 ml\/kg). Coumarin and coumarin derivatives esculetin (35 mg\/kg), scoparone (35 mg\/kg), 4-methylumbelliferone (35 mg\/kg), or coumarin (30 mg\/kg) were administered to experimental groups at 12-h intervals. Animals received the derivatives esculetin, scoparone or 4-methylumbelliferone prior to the administration of a single toxic dose of CCl\n                    <jats:sub>4.<\/jats:sub>\n                    Serum total cholesterol (TC), triglyceride (TG), very low-density lipoprotein cholesterol (VLDL-C), and low-density lipoprotein cholesterol (LDL-C) levels significantly increased in CCl\n                    <jats:sub>4<\/jats:sub>\n                    -treated group ( p &lt; 0.05, p &lt; 0.01, p &lt; 0.01, and p &lt; 0.05, respectively), while levels of serum high-density lipoprotein cholesterol (HDL-C) decreased ( p &lt; 0.01). 4-Methylumbelliferone had no recovery effects on serum TC levels, however, significantly prevented CCl\n                    <jats:sub>4<\/jats:sub>\n                    -induced hyperlipidemia by reducing TG and VLDL-C levels ( p &lt; 0.05 and p &lt; 0.05, respectively). In addition, coumarin had no recovery effect on any of the serum lipid parameters against CCl\n                    <jats:sub>4<\/jats:sub>\n                    -induced hyperlipidemia. Among the coumarin derivatives only esculetin and scoparone significantly prevented serum HDL-C in CCl\n                    <jats:sub>4<\/jats:sub>\n                    -induced dyslipidemia. The results from this study indicate that the chemical structure of coumarins plays an important role on the regulation of serum lipid profiles.\n                  <\/jats:p>","DOI":"10.1177\/0960327116649675","type":"journal-article","created":{"date-parts":[[2016,5,16]],"date-time":"2016-05-16T22:09:42Z","timestamp":1463436582000},"page":"295-301","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":31,"title":["Influence of coumarin and some coumarin derivatives on serum lipid profiles in carbontetrachloride-exposed rats"],"prefix":"10.1177","volume":"36","author":[{"given":"Ezel","family":"Ta\u015fdemir","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Medical Park Hospital, Antalya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukadder","family":"Atmaca","sequence":"additional","affiliation":[{"name":"Department of Physiology, Dicle University, Diyarbak\u0131r, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya\u015far","family":"Y\u0131ld\u0131r\u0131m","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Dicle University, Diyarbak\u0131r, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakk\u0131 Murat","family":"Bilgin","sequence":"additional","affiliation":[{"name":"Department of Physiology, Dicle University, Diyarbak\u0131r, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berjan","family":"Demirta\u015f","sequence":"additional","affiliation":[{"name":"Vocational School of Veterinary Medicine, Istanbul University, \u0130stanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basra Deniz","family":"Obay","sequence":"additional","affiliation":[{"name":"Department of Physiology, Dicle University, Diyarbak\u0131r, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Kelle","sequence":"additional","affiliation":[{"name":"Department of Physiology, Dicle University, Diyarbak\u0131r, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00fcda Diken","family":"Oflazo\u011flu","sequence":"additional","affiliation":[{"name":"Department of Physiology, Dicle University, Diyarbak\u0131r, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,7,11]]},"reference":[{"key":"bibr1-0960327116649675","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2006.11.007"},{"key":"bibr2-0960327116649675","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2009.11.020"},{"key":"bibr3-0960327116649675","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2009.05.014"},{"key":"bibr4-0960327116649675","doi-asserted-by":"publisher","DOI":"10.1016\/0009-3084(87)90063-6"},{"key":"bibr5-0960327116649675","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2008.01.017"},{"key":"bibr6-0960327116649675","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2006.04589.x"},{"key":"bibr7-0960327116649675","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(79)90167-9"},{"key":"bibr8-0960327116649675","doi-asserted-by":"publisher","DOI":"10.2754\/avb200978020229"},{"key":"bibr9-0960327116649675","doi-asserted-by":"publisher","DOI":"10.1007\/s11130-008-0083-y"},{"key":"bibr10-0960327116649675","doi-asserted-by":"publisher","DOI":"10.3109\/03602539008991449"},{"key":"bibr11-0960327116649675","doi-asserted-by":"publisher","DOI":"10.1016\/0306-3623(95)02112-4"},{"key":"bibr12-0960327116649675","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2014.05.032"},{"key":"bibr13-0960327116649675","doi-asserted-by":"publisher","DOI":"10.2217\/14622416.6.5.503"},{"key":"bibr14-0960327116649675","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.37.485"},{"key":"bibr15-0960327116649675","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2010.12.059"},{"key":"bibr16-0960327116649675","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(86)90615-5"},{"key":"bibr17-0960327116649675","doi-asserted-by":"publisher","DOI":"10.1007\/s13105-011-0103-5"},{"key":"bibr18-0960327116649675","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2010.05.023"},{"key":"bibr19-0960327116649675","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2013.09.001"},{"key":"bibr20-0960327116649675","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(01)00585-8"},{"key":"bibr21-0960327116649675","first-page":"187","volume":"78","author":"Ramesh B","year":"2005","journal-title":"Yale J Biol Med"},{"key":"bibr22-0960327116649675","doi-asserted-by":"publisher","DOI":"10.1016\/j.bionut.2014.02.003"},{"key":"bibr23-0960327116649675","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i27.4359"},{"key":"bibr24-0960327116649675","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2014.08.008"},{"key":"bibr25-0960327116649675","doi-asserted-by":"publisher","DOI":"10.1186\/1476-511X-11-126"},{"key":"bibr26-0960327116649675","first-page":"129","volume":"59","author":"Yuce B","year":"2009","journal-title":"Arzneimittelforschung"},{"key":"bibr27-0960327116649675","doi-asserted-by":"crossref","first-page":"531","DOI":"10.3839\/jksabc.2011.081","volume":"54","author":"Choi WS","year":"2011","journal-title":"J Korean Soc Appl Biol Chem"},{"key":"bibr28-0960327116649675","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2007.11.023"},{"key":"bibr29-0960327116649675","doi-asserted-by":"publisher","DOI":"10.1159\/000021978"},{"key":"bibr30-0960327116649675","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.85.95"},{"key":"bibr31-0960327116649675","first-page":"600","volume":"52","author":"Taniguchi H","year":"2004","journal-title":"Drug Res"},{"key":"bibr32-0960327116649675","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3841.2011.02381.x"},{"key":"bibr33-0960327116649675","first-page":"41","volume":"73","author":"Glende EA","year":"1991","journal-title":"Res Commun Chem Pathol Pharmacol"},{"key":"bibr34-0960327116649675","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197602052940601"},{"key":"bibr35-0960327116649675","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.89.6.2533"},{"key":"bibr36-0960327116649675","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1993.tb13993.x"},{"key":"bibr37-0960327116649675","first-page":"269","volume":"179","author":"Purohit A","year":"2006","journal-title":"Atherosclerosis"},{"key":"bibr38-0960327116649675","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2010.09.055"},{"key":"bibr39-0960327116649675","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-2797(02)00077-7"}],"container-title":["Human &amp; Experimental Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0960327116649675","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0960327116649675","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0960327116649675","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:48:58Z","timestamp":1777448938000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0960327116649675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,11]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1177\/0960327116649675"],"URL":"https:\/\/doi.org\/10.1177\/0960327116649675","relation":{},"ISSN":["0960-3271","1477-0903"],"issn-type":[{"value":"0960-3271","type":"print"},{"value":"1477-0903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,11]]}}}