{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:41:06Z","timestamp":1777668066673,"version":"3.51.4"},"reference-count":46,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2017,1,8]],"date-time":"2017-01-08T00:00:00Z","timestamp":1483833600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:p>Organochlorines (OCs) are common environmental pollutants that have been linked to cancer. This work aims to assess the role of OCs as a risk factor for breast cancer and to evaluate the cellular changes induced by exposure to such environmental contaminants. The study included 70 cancer patients subjected to thorough history taking and routine investigations. Samples from tumor and normal adjacent tissue were taken to measure OCs\u2019 levels and to perform molecular analysis (some oncogenic and apoptotic markers) by flow cytometry. There were significantly higher concentrations of methoxychlor, dichloro-diphenyl-trichloroethane (DDT), hexa-chlorobenzene (HCB), and chlordane in tumor tissue samples compared to the surrounding normal tissue. There was a positive statistically significant correlation between G2m and dichloro-diphenyl-dichloroethane, DDT, and methoxychlor. There was also a negative correlation between propidium iodide (PI) and heptachlor as well as between PI, B-cell lymphoma 2, and methoxychlor. Annexin showed a negative correlation with HCB and methoxychlor. In conclusion, the higher level of organochlorine pesticides in the tissue specimens of breast cancer and the resultant molecular dysfunction highlight a possible association. Further research is warranted to elucidate the other possible mechanisms involved in the process of carcinogenesis.<\/jats:p>","DOI":"10.1177\/0960327116685887","type":"journal-article","created":{"date-parts":[[2017,1,9]],"date-time":"2017-01-09T02:54:28Z","timestamp":1483930468000},"page":"1326-1334","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":40,"title":["Correlation between toxic organochlorine pesticides and breast cancer"],"prefix":"10.1177","volume":"36","author":[{"given":"SA","family":"Eldakroory","sequence":"first","affiliation":[{"name":"Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Mansoura University, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DA El","family":"Morsi","sequence":"additional","affiliation":[{"name":"Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Mansoura University, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RH","family":"Abdel-Rahman","sequence":"additional","affiliation":[{"name":"Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Mansoura University, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Roshdy","sequence":"additional","affiliation":[{"name":"Surgical Oncology, Oncology Centre, Mansoura University, Faculty of Medicine, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MS","family":"Gouida","sequence":"additional","affiliation":[{"name":"Molecular Immunology, Head of Flow cytometry and Genetics Units, Mansoura University Children Hospital, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EO","family":"Khashaba","sequence":"additional","affiliation":[{"name":"Occupational Medicine and Industrial Health, Public Health and Community Medicine Department, Faculty of Medicine, Mansoura University, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,1,8]]},"reference":[{"key":"bibr1-0960327116685887","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-010-9603-9"},{"key":"bibr2-0960327116685887","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2011.02.008"},{"key":"bibr3-0960327116685887","doi-asserted-by":"publisher","DOI":"10.1007\/s10661-014-4161-3"},{"key":"bibr4-0960327116685887","first-page":"111","volume":"39","author":"Abou Arab AAK","year":"2008","journal-title":"J Egypt Soc Toxicol"},{"key":"bibr5-0960327116685887","first-page":"434","volume":"4","author":"Sharaf NE","year":"2008","journal-title":"American-Eurasian J Agric Environ Sci"},{"key":"bibr6-0960327116685887","unstructured":"Nabi G, Ahmad B, Ghufran, Link between the occurrence of various forms of cancer and chronic exposure to pesticides. Basic Res J Med Clin Sci 2014; 3(12): 131\u2013135. Available at: http:\/\/www.basicresearchjournals.org\/medicine\/."},{"key":"bibr7-0960327116685887","unstructured":"Ferlay J, Soerjomataram I, Ervik M, GLOBOCAN 2012 v1.0, cancer incidence and mortality worldwide: IARC Cancer Base No. 11. Lyon: International Agency for Research on Cancer, http:\/\/globocan.iarc.fr\/2013 (accessed 10 June 2014)."},{"key":"bibr8-0960327116685887","unstructured":"World Cancer Research Fund International. http:\/\/www.wcrf.org\/index.php (2014, accessed 16 January 2016)."},{"key":"bibr9-0960327116685887","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-13-0513"},{"key":"bibr10-0960327116685887","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1158\/1055-9965.416.13.3","volume":"13","author":"Petreas M","year":"2004","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"bibr11-0960327116685887","doi-asserted-by":"publisher","DOI":"10.1016\/0248-4900(93)90116-V"},{"key":"bibr12-0960327116685887","doi-asserted-by":"publisher","DOI":"10.1155\/1998\/842306"},{"key":"bibr13-0960327116685887","doi-asserted-by":"publisher","DOI":"10.1084\/jem.180.4.1547"},{"key":"bibr14-0960327116685887","doi-asserted-by":"publisher","DOI":"10.1538\/expanim.49.97"},{"key":"bibr15-0960327116685887","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0320(20000801)40:4<346::AID-CYTO10>3.0.CO;2-W"},{"key":"bibr16-0960327116685887","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0097622"},{"key":"bibr17-0960327116685887","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrp.2014.02.001"},{"key":"bibr18-0960327116685887","doi-asserted-by":"publisher","DOI":"10.3892\/or.2015.3997"},{"key":"bibr19-0960327116685887","doi-asserted-by":"publisher","DOI":"10.1615\/JEnvironPatholToxicolOncol.2013008232"},{"key":"bibr20-0960327116685887","doi-asserted-by":"publisher","DOI":"10.1016\/S0045-6535(02)00111-X"},{"key":"bibr21-0960327116685887","first-page":"347","volume":"14","author":"Crinnion WJ","year":"2009","journal-title":"Altern Med Rev"},{"key":"bibr22-0960327116685887","doi-asserted-by":"publisher","DOI":"10.1080\/19338244.2015.1027808"},{"key":"bibr23-0960327116685887","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2015.03.045"},{"key":"bibr24-0960327116685887","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-1841"},{"key":"bibr25-0960327116685887","doi-asserted-by":"publisher","DOI":"10.1186\/1476-069X-11-28"},{"key":"bibr26-0960327116685887","doi-asserted-by":"publisher","DOI":"10.1186\/1476-069X-9-30"},{"key":"bibr27-0960327116685887","doi-asserted-by":"publisher","DOI":"10.1002\/jat.1672"},{"key":"bibr28-0960327116685887","doi-asserted-by":"publisher","DOI":"10.1186\/1476-069X-11-S1-S8"},{"key":"bibr29-0960327116685887","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-014-3005-7"},{"issue":"3","key":"bibr30-0960327116685887","doi-asserted-by":"crossref","first-page":"e0118724","DOI":"10.1371\/journal.pone.0118724","volume":"10","author":"Guiro K","year":"2015","journal-title":"Plos One"},{"key":"bibr31-0960327116685887","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.04.031"},{"key":"bibr32-0960327116685887","first-page":"527","volume":"25","author":"Fatimathas L","year":"2010","journal-title":"Histol Histopathol"},{"key":"bibr33-0960327116685887","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2009.06.021"},{"key":"bibr34-0960327116685887","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(02)00228-7"},{"key":"bibr35-0960327116685887","doi-asserted-by":"publisher","DOI":"10.1038\/nature02924"},{"key":"bibr36-0960327116685887","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfj023"},{"key":"bibr37-0960327116685887","doi-asserted-by":"publisher","DOI":"10.1038\/364806a0"},{"key":"bibr38-0960327116685887","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.99107s189"},{"key":"bibr39-0960327116685887","doi-asserted-by":"publisher","DOI":"10.1016\/S0013-9351(03)00047-1"},{"key":"bibr40-0960327116685887","doi-asserted-by":"publisher","DOI":"10.1002\/tox.20775"},{"key":"bibr41-0960327116685887","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119718"},{"key":"bibr42-0960327116685887","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2013.11.002"},{"key":"bibr43-0960327116685887","doi-asserted-by":"publisher","DOI":"10.1002\/tox.21882"},{"key":"bibr44-0960327116685887","doi-asserted-by":"publisher","DOI":"10.1021\/tx100231n"},{"key":"bibr45-0960327116685887","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2015.08.016"},{"key":"bibr46-0960327116685887","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2016.02.003"}],"container-title":["Human &amp; Experimental Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0960327116685887","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0960327116685887","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0960327116685887","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:48:51Z","timestamp":1777448931000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0960327116685887"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,8]]},"references-count":46,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1177\/0960327116685887"],"URL":"https:\/\/doi.org\/10.1177\/0960327116685887","relation":{},"ISSN":["0960-3271","1477-0903"],"issn-type":[{"value":"0960-3271","type":"print"},{"value":"1477-0903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,8]]}}}