{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:44:00Z","timestamp":1777668240147,"version":"3.51.4"},"reference-count":42,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T00:00:00Z","timestamp":1487635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Liver fibrosis is a noteworthy well-being issue that can prompt the progression of liver cirrhosis and hepatocellular carcinoma. Prominently, many antioxidants have been shown to have defensive impacts against liver fibrosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>\n                      Subsequently, in the present study, the viability of alpha-lipoic acid (\u03b1-LA) in ensuring against carbon tetrachloride (CCl\n                      <jats:sub>4<\/jats:sub>\n                      )-actuated liver fibrosis and the mechanism(s) involved in this defensive impact were considered in rats.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The present results uncovered that in the CCl\n                      <jats:sub>4<\/jats:sub>\n                      -treated group, the expression of antioxidant enzymes and matrix metalloproteinase-13 (MMP-13) messenger RNA (mRNA) was downregulated ( p &lt; 0.05), and the levels of lipid peroxide and nitric oxide were increased ( p &lt; 0.05) in the treated rat livers along with increased collagen deposition compared to that of the control group. Also, the gene expression levels of the proinflammatory factors interleukin-6 and tumor necrosis factor-alpha, nuclear factor-kappa B (NF-\u03baB) p65, transforming growth factor-alpha, and inducible nitric oxide synthase (iNOS) were upregulated significantly ( p &lt; 0.05) in the CCl\n                      <jats:sub>4<\/jats:sub>\n                      group. These negative impacts were all restrained by \u03b1-LA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>These outcomes show that \u03b1-LA might be compelling at forestalling collagen deposition and hepatic oxidative stress as well as downregulating the expression of hepatic proinflammatory cytokines, iNOS, and NF-\u03baB and upregulating MMP-13 expression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0960327117693066","type":"journal-article","created":{"date-parts":[[2017,2,22]],"date-time":"2017-02-22T01:43:37Z","timestamp":1487727817000},"page":"142-154","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":36,"title":["Molecular hepatoprotective effects of lipoic acid against carbon tetrachloride-induced liver fibrosis in 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