{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T19:08:35Z","timestamp":1788030515781,"version":"build-2784847793"},"reference-count":55,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2017,4,17]],"date-time":"2017-04-17T00:00:00Z","timestamp":1492387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:p>To investigate the underlying mechanism of neurotoxicity of cadmium, we examined the effects of intraperitoneal injection of cadmium on messenger RNA (mRNA) expression of Bcl-2 (B-cell lymphoma 2) and Bax (Bcl2-associated x) genes and caspase-3\/7 activation in rat hippocampus and frontal cortex. Twenty-eight male Wistar rats weighing 200\u2013250 g were randomly divided into four groups. Control group received saline and three other groups received cadmium at doses of 1, 2 and 4 mg\/kg (body weight) for 15 successive days. One day after the last injection, the hippocampus and frontal cortex were dissected and removed and then the expression of Bcl-2 and Bax genes was evaluated using real-time polymerase chain reaction and apoptotic studies was done using caspase-3\/7 activation assay. Cadmium reduced the mRNA level of Bcl-2 in the control group at doses of 1 ( p &lt; 0.01), 2 and 4 mg\/kg ( p &lt; 0.001) in rat hippocampus and cortex cells. The mRNA level of Bax increased significantly compared to the control group at the doses of 1 ( p &lt; 0.05), 2 and 4 mg\/kg ( p &lt; 0.001) in rat hippocampus. The mRNA level of Bax was increased significantly compared to the control group at the doses of 2 and 4 mg\/kg ( p &lt; 0.001) in rat cortex cells. Cadmium increased caspase-3\/7 activity at doses of 1, 2 and 4 mg\/kg in rat hippocampus. Caspase-3\/7 activity was increased significantly at dose of 4 mg\/kg in rat cortex. This decreased Bcl-2\/Bax mRNA ratio induces cell apoptosis. Apoptotic effect of cadmium may be through the mitochondrial pathway by the activation of caspase-3\/7.<\/jats:p>","DOI":"10.1177\/0960327117703687","type":"journal-article","created":{"date-parts":[[2017,4,17]],"date-time":"2017-04-17T07:57:28Z","timestamp":1492415848000},"page":"321-328","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":59,"title":["Effects of cadmium on\n                    <i>Bcl-2<\/i>\n                    \/\n                    <i>Bax<\/i>\n                    expression ratio in rat cortex brain and hippocampus"],"prefix":"10.1177","volume":"37","author":[{"given":"S","family":"Mahdavi","sequence":"first","affiliation":[{"name":"Department of Biology, Parand Branch, Islamic Azad University, Parand, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Khodarahmi","sequence":"additional","affiliation":[{"name":"Department of Biology, Parand Branch, Islamic Azad 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