{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:37:13Z","timestamp":1777667833378,"version":"3.51.4"},"reference-count":32,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T00:00:00Z","timestamp":1493078400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:p>The aim of this study was to assess changes in bone mineral density (BMD) and cadmium (Cd) levels in blood and urine in individuals living in a Cd-contaminated area according to the type of osteoporosis medication over a three-year period. This follow-up study included 204 residents living in the vicinity of a closed copper refinery, who had been found to have elevated urinary or blood Cd levels. Cd levels in the blood and urine, as well as BMD, were measured every 6 months. After the first BMD measurement, individuals were prescribed antiresorptives such as alendronate or vitamin D and calcium, according to their BMD. Subjects were classified according to the type of medicine provided over the previous 6 months. General linear models controlling for other factors were used to evaluate the effects of each type of medication on the participants\u2019 Cd levels and BMD. Spinal BMD showed a significant increase in the antiresorptive group compared to the nontreatment group. Significant decreases in blood Cd levels were found in the vitamin D and calcium group, in comparison to the nontreatment group, as well as a marginally significant decrease in the antiresorptive group. The vitamin D and calcium group showed a significantly greater decrease in urinary Cd levels than the nontreatment group. In contrast, antiresorptive medication was found to have a negative effect on urinary Cd excretion. These results suggest that vitamin D and calcium treatment for osteoporosis lowers blood Cd levels more effectively and improves urinary Cd excretion.<\/jats:p>","DOI":"10.1177\/0960327117705425","type":"journal-article","created":{"date-parts":[[2017,4,26]],"date-time":"2017-04-26T02:41:35Z","timestamp":1493174495000},"page":"350-357","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Changes in blood and urinary cadmium levels and bone mineral density according to osteoporosis medication in individuals with an increased cadmium body burden"],"prefix":"10.1177","volume":"37","author":[{"given":"S-Y","family":"Eom","sequence":"first","affiliation":[{"name":"Department of Preventive Medicine, College of Medicine, Chungbuk National University, Cheongju, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D-H","family":"Yim","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, College of Medicine, Chungbuk National University, Cheongju, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S-M","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, College of Medicine, Chungbuk National University, Cheongju, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y-D","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, College of Medicine, Chungbuk National University, Cheongju, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, College of Medicine, Chungbuk National University, Cheongju, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B-S","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Chung-Ang University College of 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