{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T06:06:40Z","timestamp":1778220400685,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2017,7,25]],"date-time":"2017-07-25T00:00:00Z","timestamp":1500940800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:p>\n                    Acute lung injury (ALI) is a major outcome of exposure to high levels of hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S). Dexamethasone (DXM) has been used to treat ALI. However, the mechanisms involved in H\n                    <jats:sub>2<\/jats:sub>\n                    S-induced ALI and the protective mechanisms of DXM in treating ALI are still nebulous. To explore the mechanisms involved, we evaluated the role of claudin-5 in the protective effect of DXM against H\n                    <jats:sub>2<\/jats:sub>\n                    S-induced ALI. Sprague-Dawley rats were exposed to H\n                    <jats:sub>2<\/jats:sub>\n                    S to establish the ALI model. In parallel with the animal model, a cell model was also established by incubating human umbilical vein endothelial cells (HUVECs) with NaHS. Lung hematoxylin\u2013eosin staining, electron microscope assay, and wet\/dry ratio were used to identify whether the ALI was successfully induced by H\n                    <jats:sub>2<\/jats:sub>\n                    S, and changes in claudin-5 expression were detected in both rats and HUVECs. Our results revealed that claudin-5 was markedly decreased after H\n                    <jats:sub>2<\/jats:sub>\n                    S exposure and that DXM significantly attenuated the H\n                    <jats:sub>2<\/jats:sub>\n                    S-induced downregulation of claudin-5 in both rats and HUVECs. In the animal experiment, p-Akt and p-FoxO\n                    <jats:sub>1<\/jats:sub>\n                    presented a similar tendency as claudin-5, but their levels decreased 6 h prior to the levels of claudin-5. In a further investigation, the DXM-induced protective effect on ALI and rescue effect on downregulation of claudin-5 were both blocked by LY294002. The current study demonstrated that claudin-5 was involved in the development of H\n                    <jats:sub>2<\/jats:sub>\n                    S-induced ALI and that DXM exerted protective effects through increasing claudin-5 expression by activating the phosphatidylinositol 3-kinase pathway. Therefore, claudin-5 might represent a novel pharmacological target for treating ALI induced by H\n                    <jats:sub>2<\/jats:sub>\n                    S and other hazardous gases.\n                  <\/jats:p>","DOI":"10.1177\/0960327117721961","type":"journal-article","created":{"date-parts":[[2017,7,25]],"date-time":"2017-07-25T07:35:14Z","timestamp":1500968114000},"page":"626-635","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Dexamethasone ameliorates H\n                    <sub>2<\/sub>\n                    S-induced acute lung injury by           increasing claudin-5 expression via the PI3K pathway"],"prefix":"10.1177","volume":"37","author":[{"given":"P","family":"Geng","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, The First Affiliated Hospital to Nanjing\r        Medical University, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, The First Affiliated Hospital to Nanjing\r        Medical University, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, The First Affiliated Hospital to Nanjing\r        Medical University, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, The First Affiliated Hospital to Nanjing\r        Medical University, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, The First Affiliated Hospital to Nanjing\r        Medical University, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Occupational Disease Prophylactic-Therapeutic Institution,\r        Jiangsu Provincial Center for Disease Prevention and Control, Nanjing, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Occupational Disease Prophylactic-Therapeutic Institution,\r        Jiangsu Provincial Center for Disease Prevention and Control, Nanjing, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Xiao","sequence":"additional","affiliation":[{"name":"Key Lab of Modern Toxicology (NJMU), Ministry of Education, Department of\r        Toxicology, School of Public Health, Nanjing Medical University, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Lab of Modern Toxicology (NJMU), Ministry of Education, Department of\r        Toxicology, School of Public Health, Nanjing Medical University, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, The First Affiliated Hospital to Nanjing\r        Medical University, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,7,25]]},"reference":[{"key":"bibr1-0960327117721961","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.01038"},{"key":"bibr2-0960327117721961","doi-asserted-by":"publisher","DOI":"10.3109\/10408448409029321"},{"key":"bibr3-0960327117721961","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-0362(99)00055-0"},{"key":"bibr4-0960327117721961","doi-asserted-by":"publisher","DOI":"10.1007\/s00414-007-0172-8"},{"key":"bibr5-0960327117721961","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00047810"},{"key":"bibr6-0960327117721961","doi-asserted-by":"publisher","DOI":"10.1038\/ncb0808-883"},{"key":"bibr7-0960327117721961","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2011.3893"},{"key":"bibr8-0960327117721961","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2011.01.028"},{"key":"bibr9-0960327117721961","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-11-59"},{"key":"bibr10-0960327117721961","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200302070"},{"key":"bibr11-0960327117721961","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1752"},{"key":"bibr12-0960327117721961","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2009-0391OC"},{"key":"bibr13-0960327117721961","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-11980"},{"key":"bibr14-0960327117721961","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2012.01.014"},{"key":"bibr15-0960327117721961","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00828.2009"},{"key":"bibr16-0960327117721961","doi-asserted-by":"crossref","unstructured":"Al-Harbi 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