{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:39:24Z","timestamp":1777667964357,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2018,5,16]],"date-time":"2018-05-16T00:00:00Z","timestamp":1526428800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"The Danish Working Environment Research Fund","award":["Danish Centre for Nanosafety I + II"],"award-info":[{"award-number":["Danish Centre for Nanosafety I + II"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>\n                    Little is known on the toxicity of nanomaterials in the user phase. Inclusion of nanomaterials in paints is a common nanotechnology application. This study focuses on the toxicity of dusts from sanding of paints containing nanomaterials. We compared the toxicity of titanium dioxide nanomaterials (TiO\n                    <jats:sub>2<\/jats:sub>\n                    NMs) and dusts generated by sanding boards coated with paints with different amounts of two different types of uncoated TiO\n                    <jats:sub>2<\/jats:sub>\n                    NMs (diameters:10.5 nm and 38 nm). Mice were intratracheally instilled with a single dose of 18, 54 and 162 \u00b5g of TiO\n                    <jats:sub>2<\/jats:sub>\n                    NMs or 54, 162 and 486 \u00b5g of sanding dusts. At 1, 3 and 28 days post-instillation, we evaluated pulmonary inflammation, liver histology and DNA damage in lung and liver. Pulmonary exposure to both pristine TiO\n                    <jats:sub>2<\/jats:sub>\n                    NMs and sanding dusts with different types of TiO\n                    <jats:sub>2<\/jats:sub>\n                    NMs resulted in dose-dependently increased influx of neutrophils into the lung lumen. There was no difference between the sanding dusts from the two paints. For all exposures but not in vehicle controls, mild histological lesions were observed in the liver. Pulmonary exposure to pristine TiO\n                    <jats:sub>2<\/jats:sub>\n                    NMs and paint dusts with TiO\n                    <jats:sub>2<\/jats:sub>\n                    NMs caused similar type of histological lesions in the liver.\n                  <\/jats:p>","DOI":"10.1177\/0960327118774910","type":"journal-article","created":{"date-parts":[[2018,5,16]],"date-time":"2018-05-16T05:57:43Z","timestamp":1526450263000},"page":"11-24","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":36,"title":["Toxicity of pristine and paint-embedded TiO\n                    <sub>2<\/sub>\n                    nanomaterials"],"prefix":"10.1177","volume":"38","author":[{"given":"AT","family":"Saber","sequence":"first","affiliation":[{"name":"The National Research Centre for the Working Environment, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Mortensen","sequence":"additional","affiliation":[{"name":"The National Research Centre for the Working Environment, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Szarek","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NR","family":"Jacobsen","sequence":"additional","affiliation":[{"name":"The National Research Centre for the Working Environment, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Levin","sequence":"additional","affiliation":[{"name":"The National Research Centre for the Working Environment, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"IK","family":"Koponen","sequence":"additional","affiliation":[{"name":"The National Research Centre for the Working Environment, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KA","family":"Jensen","sequence":"additional","affiliation":[{"name":"The National Research Centre for the Working Environment, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U","family":"Vogel","sequence":"additional","affiliation":[{"name":"The National Research Centre for the Working Environment, Copenhagen, Denmark"},{"name":"Department of Micro and Nanotechnology, Technical University of Denmark, Lyngby, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Wallin","sequence":"additional","affiliation":[{"name":"The National Research Centre for the Working Environment, Copenhagen, Denmark"},{"name":"Present address: National Institute of Occupational Health, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,5,16]]},"reference":[{"key":"bibr1-0960327118774910","unstructured":"The Nanodatabase, http:\/\/nanodb.dk (2016, accessed 14 July 2016)."},{"key":"bibr2-0960327118774910","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201002054"},{"key":"bibr3-0960327118774910","doi-asserted-by":"publisher","DOI":"10.3109\/17435390.2011.620745"},{"key":"bibr4-0960327118774910","doi-asserted-by":"publisher","DOI":"10.1186\/1743-8977-9-4"},{"key":"bibr5-0960327118774910","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfu112"},{"key":"bibr6-0960327118774910","volume-title":"Nanotechnology: technical basics and applications","author":"Sepeur S","year":"2008"},{"key":"bibr7-0960327118774910","doi-asserted-by":"publisher","DOI":"10.1186\/1743-8977-10-15"},{"key":"bibr8-0960327118774910","doi-asserted-by":"publisher","DOI":"10.3109\/17435390.2011.587900"},{"key":"bibr9-0960327118774910","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/gew046"},{"key":"bibr10-0960327118774910","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2013.03.018"},{"key":"bibr11-0960327118774910","unstructured":"IARC. Carbon Black, Titanium Dioxide, and Talc. IARC Working Group on the evaluation of carcinogenic risks to humans. The International Agency for Research on Cancer. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, vol. 93. Lyon: WHO, 2010, p. 193\u2013276."},{"key":"bibr12-0960327118774910","unstructured":"https:\/\/chemicalwatch.com\/43791\/france-proposes-carcinogen-1b-classification-for-titanium-dioxide (2016, accessed 14 July 2016)."},{"key":"bibr13-0960327118774910","doi-asserted-by":"publisher","DOI":"10.1186\/s12989-016-0148-2"},{"key":"bibr14-0960327118774910","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/get049"},{"key":"bibr15-0960327118774910","doi-asserted-by":"publisher","DOI":"10.1080\/10937404.2015.1126210"},{"key":"bibr16-0960327118774910","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-004-0613-9"},{"key":"bibr17-0960327118774910","doi-asserted-by":"publisher","DOI":"10.1186\/1743-8977-6-2"},{"key":"bibr18-0960327118774910","first-page":"983","volume":"58","author":"Gomez V","year":"2014","journal-title":"Ann Occup Hyg"},{"key":"bibr19-0960327118774910","doi-asserted-by":"publisher","DOI":"10.1002\/em.21936"},{"key":"bibr20-0960327118774910","doi-asserted-by":"publisher","DOI":"10.1186\/1743-8977-7-16"},{"key":"bibr21-0960327118774910","doi-asserted-by":"publisher","DOI":"10.3109\/17435390.2011.633715"},{"key":"bibr22-0960327118774910","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/55.1.24"},{"key":"bibr23-0960327118774910","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfj123"},{"key":"bibr24-0960327118774910","doi-asserted-by":"publisher","DOI":"10.1080\/08958370050166796"},{"key":"bibr25-0960327118774910","doi-asserted-by":"publisher","DOI":"10.1089\/089426802320282338"},{"key":"bibr26-0960327118774910","doi-asserted-by":"publisher","DOI":"10.3109\/17435390.2014.996192"},{"key":"bibr27-0960327118774910","first-page":"15","volume":"2","author":"Modrzynska J","year":"2018","journal-title":"Part Fibre Toxicol"},{"key":"bibr28-0960327118774910","doi-asserted-by":"publisher","DOI":"10.1038\/jes.2010.32"}],"container-title":["Human &amp; Experimental Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0960327118774910","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0960327118774910","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0960327118774910","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:48:27Z","timestamp":1777448907000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0960327118774910"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,16]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1177\/0960327118774910"],"URL":"https:\/\/doi.org\/10.1177\/0960327118774910","relation":{},"ISSN":["0960-3271","1477-0903"],"issn-type":[{"value":"0960-3271","type":"print"},{"value":"1477-0903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,16]]}}}