{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:49:18Z","timestamp":1791600558235,"version":"4.3.4"},"reference-count":72,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2018,6,13]],"date-time":"2018-06-13T00:00:00Z","timestamp":1528848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100006312","name":"South African Agency for Science and Technology Advancement","doi-asserted-by":"publisher","award":["90550"],"award-info":[{"award-number":["90550"]}],"id":[{"id":"10.13039\/501100006312","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Nitrogen oxide (NOx) pollution and human immunodeficiency virus (HIV)\/AIDS intensify inflammation during pregnancy and linked with adverse birth outcomes (ABOs). MicroRNA (miRNA)-146a plays a crucial role in regulating inflammation in the NF-\u03baB pathway. The G\/C rs2910164 dampens miRNA-146a activity and linked with inflammatory diseases. The present study investigated whether HIV\/AIDS and NOx exposure throughout pregnancy further intensifies ABO in Black South African women genotyped for the rs2910164.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Pregnant women ( n = 300) were subdivided into low, medium and high NOx exposure groups, genotyped for the miRNA-146a G\/C rs2910164 using polymerase chain reaction-restriction fragment length polymorphism, and further stratified based on HIV status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Unstratified data (HIV+ and HIV\u2212 mothers combined): Mothers from the high NOx group with the variant C-allele had low blood iron levels ( p = 0.0238), and had babies with reduced birthweights ( p = 0.0283). As NOx increased, the prevalence of preterm birth and low birth weight also increased in mothers with the variant C-allele versus wildtype G-allele. HIV-infected mothers: In all NOx exposure groups, mothers with the variant C-allele had higher systolic blood pressure (low: p = 0.0386, medium: p = 0.0367 and high: p = 0.0109) and had babies with lower Appearance, Pulse, Grimace, Activity and Respiration scores at 1 min (low: p = 0.0190, medium: p = 0.0301 and high: p = 0.0361).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Maternal rs2910164 variant C-allele, NOx pollution and HIV\/AIDS might collectively play a role in intensifying gestational hypertension and ABO.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0960327118781902","type":"journal-article","created":{"date-parts":[[2018,6,15]],"date-time":"2018-06-15T10:40:50Z","timestamp":1529059250000},"page":"82-94","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Maternal miRNA-146a G\/C rs2910164 variation, HIV\/AIDS and nitrogen oxide pollution exposure collectively affects foetal growth"],"prefix":"10.1177","volume":"38","author":[{"given":"P","family":"Naidoo","sequence":"first","affiliation":[{"name":"Discipline of Medical Biochemistry and Chemical Pathology, University of KwaZulu-Natal, Durban, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RN","family":"Naidoo","sequence":"additional","affiliation":[{"name":"Discipline of Occupational and Environmental Health, University of KwaZulu-Natal, Durban, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Ramkaran","sequence":"additional","affiliation":[{"name":"Discipline of Medical Biochemistry and Chemical Pathology, University of KwaZulu-Natal, Durban, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Muttoo","sequence":"additional","affiliation":[{"name":"Discipline of Occupational and 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