{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:40:07Z","timestamp":1777668007254,"version":"3.51.4"},"reference-count":50,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T00:00:00Z","timestamp":1540425600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81472947"],"award-info":[{"award-number":["81472947"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:p>\n                    Previous studies indicated that exposure to fine particulate matter (PM\n                    <jats:sub>2.5<\/jats:sub>\n                    ) was related to pulmonary inflammatory diseases through activation of nuclear factor kappa B (NF-\u03baB) signaling pathway to trigger cytokine secretions in human lung carcinoma cells. To investigate the potential mechanisms underlying expression of cytokines via activated NF-\u03baB by PM\n                    <jats:sub>2.5<\/jats:sub>\n                    , human bronchial epithelial cells (BEAS-2B cells) were treated with PM\n                    <jats:sub>2.5<\/jats:sub>\n                    extracts at different concentrations (6, 13, 25, 50, 100, 200, and 400 \u00b5g mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) for 6 and 24 h. We found that 100 \u00b5g mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    PM\n                    <jats:sub>2.5<\/jats:sub>\n                    increased interleukin 6 (IL-6) and IL-8 expression at 24 h ( p &lt; 0.05 or p &lt; 0.01). Moreover, 100 \u00b5g mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    PM\n                    <jats:sub>2.5<\/jats:sub>\n                    upregulated phosphorylated I\u03baB kinase (IKK), p65, and I\u03baB\u03b1 at 6 h, which could be reversed by the IKK inhibitor Bay11-7082 ( p &lt; 0.05 or p &lt; 0.01). The p65 subunit of NF-\u03baB was translocated into the nucleus of the cells treated with 100 \u00b5g mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    PM\n                    <jats:sub>2.5<\/jats:sub>\n                    at 6 and 24 h. Bay11-7082 partly inhibited PM\n                    <jats:sub>2.5<\/jats:sub>\n                    -induced increases of IL-6 and IL-8 secretion. The results indicated that PM\n                    <jats:sub>2.5<\/jats:sub>\n                    extract increased IL-6 and IL-8 levels in BEAS-2B cells through activation of IKK\/NF-\u03baB pathway. Our study will contribute to better understanding of the mechanism of PM\n                    <jats:sub>2.5<\/jats:sub>\n                    -induced pulmonary inflammatory diseases.\n                  <\/jats:p>","DOI":"10.1177\/0960327118802628","type":"journal-article","created":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T07:24:56Z","timestamp":1540452296000},"page":"311-320","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["PM\n                    <sub>2.5<\/sub>\n                    stimulated the release of cytokines from BEAS-2B cells through activation of IKK\/NF-\n                    <i>\u03ba<\/i>\n                    B pathway"],"prefix":"10.1177","volume":"38","author":[{"given":"J","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Occupational and Environmental Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 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