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Male Wistar rats were exposed orally, daily through drinking water to 0 ppm (control), 150 ppm, 300 ppm, and 600 ppm of CoCl\n                    <jats:sub>2<\/jats:sub>\n                    , respectively. Following exposure, results revealed significant ( p &lt; 0.05) rise in markers of oxidative stress, but decreased activities of catalase, glutathione peroxidase, glutathione-S-transferase, and reduced glutathione content in cardiac and renal tissues. There were significant increases in systolic, diastolic, and mean arterial blood pressure at the 300- and 600-ppm level of CoCl\n                    <jats:sub>2<\/jats:sub>\n                    -exposed rats relative to the control. Prolongation of QT and QTc intervals was observed in CoCl\n                    <jats:sub>2<\/jats:sub>\n                    alone treated rats. Also, there were significant increases in the heart rates, and reduction in P wave, and PR duration of rats administered CoCl\n                    <jats:sub>2<\/jats:sub>\n                    . Histopathology of the kidney revealed peritubular and periglomerular inflammation, focal glomerular necrosis following CoCl\n                    <jats:sub>2<\/jats:sub>\n                    exposure. Further, cyclooxygenase-2 and B-cell associated protein X expressions were upregulated in the cardiac and renal tissues of CoCl\n                    <jats:sub>2<\/jats:sub>\n                    -exposed rats relative to the control. Combining all, results from this study implicated oxidative stress, inflammation, and apoptosis as pathologic mechanisms in CoCl\n                    <jats:sub>2<\/jats:sub>\n                    -induced hypertension and cardiovascular complications of rats.\n                  <\/jats:p>","DOI":"10.1177\/0960327118812158","type":"journal-article","created":{"date-parts":[[2018,12,31]],"date-time":"2018-12-31T05:58:17Z","timestamp":1546235897000},"page":"519-532","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":53,"title":["Cobalt chloride toxicity elicited hypertension and cardiac complication via induction of oxidative stress and upregulation of COX-2\/Bax signaling pathway"],"prefix":"10.1177","volume":"38","author":[{"given":"AA","family":"Oyagbemi","sequence":"first","affiliation":[{"name":"Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TO","family":"Omobowale","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"OV","family":"Awoyomi","sequence":"additional","affiliation":[{"name":"Federal College of Animal Health and Production Technology, Moor Plantation, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TO","family":"Ajibade","sequence":"additional","affiliation":[{"name":"Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"OO","family":"Falayi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BS","family":"Ogunpolu","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"UJ","family":"Okotie","sequence":"additional","affiliation":[{"name":"Federal College of Animal Health and Production Technology, Moor Plantation, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ER","family":"Asenuga","sequence":"additional","affiliation":[{"name":"Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Benin, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"OA","family":"Adejumobi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FO","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"OE","family":"Ola-Davies","sequence":"additional","affiliation":[{"name":"Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AB","family":"Saba","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AA","family":"Adedapo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MA","family":"Yakubu","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria"},{"name":"Department of Environmental and Interdisciplinary Sciences, College of Science, Engineering and Technology, Vascular Biology Unit, Center for Cardiovascular Diseases, COPHS, Texas Southern University, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,12,31]]},"reference":[{"key":"bibr1-0960327118812158","doi-asserted-by":"publisher","DOI":"10.1539\/joh.43.1"},{"key":"bibr2-0960327118812158","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2012.06.009"},{"key":"bibr3-0960327118812158","volume-title":"Cobalt and cobalt compounds. 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