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Isoproterenol hydrochloride (ISO; 85 mg\/kg body weight) was administered subcutaneously for first two consecutive days. ISO-induced MI in rats significantly decreased the activities of mitochondrial tricarboxylic acid cycle enzymes and respiratory chain enzymes while increased the activities of lysosomal glycohydrolases and cathepsins. The expression of matrix metalloproteinase 2 (MMP-2), MMP-9, collagen type I, \u03b1-smooth muscle actin (\u03b1-SMA), and transforming growth factor-\u03b2 (TGF-\u03b2) were upregulated in ISO-induced MI in rats. UA administration to rats showed increased activities of mitochondrial tricarboxylic acid cycle enzymes and respiratory chain enzymes and decreased activities of lysosomal glycohydrolases and cathepsins in ISO-induced rats. Furthermore, expression of MMP-2, MMP-9, collagen type I, \u03b1-SMA, and TGF-\u03b2 downregulated in UA-administered rats. Thus, our results demonstrate that UA has an anti-fibrotic effect and attenuates the mitochondrial and lysosomal dysfunction in ISO-induced MI in rats.<\/jats:p>","DOI":"10.1177\/0960327119842620","type":"journal-article","created":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T05:12:19Z","timestamp":1555045939000},"page":"785-793","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":35,"title":["Ursolic acid modulates MMPs, collagen-I, \u03b1-SMA, and TGF-\u03b2 expression in isoproterenol-induced myocardial infarction in rats"],"prefix":"10.1177","volume":"38","author":[{"given":"T","family":"Radhiga","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Chidambaram, Tamil Nadu, 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