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The most common environmental factors that may cause orofacial clefts include pharmaceuticals, alcohol, addictive drugs, and tobacco smoke. Living in the area of industrial factories, garbage, ironworks, crematoria, wastewater treatment plants, and plastic waste landfills also has a significant impact on the development of the craniofacial defects. Some of the main factors causing the formation of congenital craniofacial defects are dioxins, of which emission to the environment is an important environmental and health problem. Dioxins are a diverse group of organic chemical compounds, derivatives of oxanthrene and fumarates, which are organoleptically imperceptible. Acting mainly through induction of inflammation, they influence a number of metabolic processes, including the process of bone mineralization and embryonic development. In this work, we highlight the problem of orofacial cleft including the impact of dioxin on development of this defect and the recommended prevention.<\/jats:p>","DOI":"10.1177\/0960327119855121","type":"journal-article","created":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T07:33:11Z","timestamp":1559806391000},"page":"1014-1023","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Can contamination of the environment by dioxins cause craniofacial defects?"],"prefix":"10.1177","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3826-0452","authenticated-orcid":false,"given":"A","family":"Le\u015bk\u00f3w","sequence":"first","affiliation":[{"name":"Department of Nervous System Diseases, Faculty of Health Sciences, Wroclaw Medical University, Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Nawrocka","sequence":"additional","affiliation":[{"name":"Department of Nervous System Diseases, Faculty of Health Sciences, Wroclaw Medical University, Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"\u0141\u0105tkowska","sequence":"additional","affiliation":[{"name":"Department of Nervous System Diseases, Faculty of Health Sciences, Wroclaw Medical University, Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Tarnowska","sequence":"additional","affiliation":[{"name":"Department of Nervous System Diseases, Faculty of Health Sciences, Wroclaw Medical University, Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Galas","sequence":"additional","affiliation":[{"name":"Department of Nervous System Diseases, Faculty of Health Sciences, Wroclaw Medical University, Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Matejuk","sequence":"additional","affiliation":[{"name":"Department of Nervous System Diseases, Faculty of Health Sciences, Wroclaw Medical University, Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Ca\u0142kosi\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Nervous System Diseases, Faculty of Health Sciences, Wroclaw Medical University, Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,6,6]]},"reference":[{"key":"bibr1-0960327119855121","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2933"},{"key":"bibr2-0960327119855121","doi-asserted-by":"publisher","DOI":"10.1016\/j.cps.2013.12.003"},{"key":"bibr3-0960327119855121","doi-asserted-by":"publisher","DOI":"10.4103\/0970-0358.57182"},{"key":"bibr4-0960327119855121","doi-asserted-by":"publisher","DOI":"10.1111\/joor.12204"},{"key":"bibr5-0960327119855121","doi-asserted-by":"publisher","DOI":"10.1177\/154405910408300211"},{"key":"bibr6-0960327119855121","doi-asserted-by":"publisher","DOI":"10.5604\/12321966.1120594"},{"key":"bibr7-0960327119855121","volume-title":"Division palatine: Anatomie, chirurgie, phonetique","author":"Veau V","year":"1931"},{"key":"bibr8-0960327119855121","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2014.00163"},{"key":"bibr9-0960327119855121","first-page":"30","volume-title":"What is a Cleft Lip and Palate?: A Multidisciplinary Update","author":"Kriens O","year":"1989"},{"key":"bibr10-0960327119855121","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-195811000-00001"},{"key":"bibr11-0960327119855121","first-page":"384","volume-title":"Head and neck surgery","author":"Kobus K.","year":"2004"},{"key":"bibr12-0960327119855121","volume-title":"Wrodzone wady rozwojowe w Polsce w latach 1998\u20131999. 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