{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T05:16:38Z","timestamp":1781327798375,"version":"3.54.1"},"reference-count":44,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Scientific Research Project Coordination Unit of Istanbul University","award":["52327"],"award-info":[{"award-number":["52327"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:p>Galectin-1 is an important mediator that regulates the T-cell-mediated immune response. It has many other biological functions such as cell growth, immunomodulation, and wound healing. The aim of this study was to reveal the role of galectin-1 on liver morphology, cell proliferation, apoptosis, inflammatory and anti-inflammatory mediators, oxidative stress, and antioxidant system in colitis-mediated hepatotoxicity induced by dextran sulfate sodium (DSS). In the present study, adult mice were divided into four groups: The control group intraperitoneally injected with phosphate buffer saline (I), the group which was orally administered with DSS (II), the control group which was injected with galectin-1 (III), and the group which was given DSS and galectin-1 (IV). DSS administration caused degenerative changes and diffuse necrotic damage, an increase in caspase-3 and cyclooxygenase-2 expression, the levels of lipid peroxidation and tumor necrosis factor-alpha, lactate dehydrogenase, and myeloperoxidase activities, and a decrease in cell proliferation, interleukin-10 levels, and antioxidant system parameters in liver tissues. Treatment of DSS group with galectin-1 reversed these effects and prevented liver damage. This study showed that galectin-1 has proliferative, antiapoptotic, anti-inflammatory, and antioxidant effects against DSS-induced liver injury in mice. It is expected considering all results of this study that galectin-1 may be useful as a protective agent against liver toxicity.<\/jats:p>","DOI":"10.1177\/0960327119891224","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T07:55:33Z","timestamp":1575273333000},"page":"423-432","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Galectin-1 exhibits a protective effect against hepatotoxicity induced by dextran sulfate sodium in mice"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7958-6977","authenticated-orcid":false,"given":"P","family":"Arda-Pirincci","sequence":"first","affiliation":[{"name":"Division of Molecular Biology, Department of Biology, Faculty of Science, Istanbul University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Sacan","sequence":"additional","affiliation":[{"name":"Division of Biochemistry, Department of Chemistry, Faculty of Engineering, Istanbul University\u2013Cerrahpasa, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Ozal-Coskun","sequence":"additional","affiliation":[{"name":"Section of Biology, Institute of Graduate Studies in Sciences, Istanbul University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Aykol-Celik","sequence":"additional","affiliation":[{"name":"Section of Biology, Institute of Graduate Studies in Sciences, Istanbul University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Karabulut-Bulan","sequence":"additional","affiliation":[{"name":"Division of General Biology, Department of Biology, Faculty of Science, Istanbul University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Yanardag","sequence":"additional","affiliation":[{"name":"Division of Biochemistry, Department of Chemistry, Faculty of Engineering, Istanbul University\u2013Cerrahpasa, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Bolkent","sequence":"additional","affiliation":[{"name":"Division of Molecular Biology, Department of Biology, Faculty of Science, Istanbul University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,12,1]]},"reference":[{"key":"bibr1-0960327119891224","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2001.00981.x"},{"issue":"4","key":"bibr2-0960327119891224","first-page":"235","volume":"7","author":"Levine JS","year":"2011","journal-title":"Gastroenterol Hepatol"},{"key":"bibr3-0960327119891224","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-019-0967-3"},{"key":"bibr4-0960327119891224","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2009.10.011"},{"key":"bibr5-0960327119891224","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i33.4193"},{"key":"bibr6-0960327119891224","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/718617"},{"key":"bibr7-0960327119891224","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90498-7"},{"key":"bibr8-0960327119891224","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.10.5198"},{"key":"bibr9-0960327119891224","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwl025"},{"key":"bibr10-0960327119891224","doi-asserted-by":"publisher","DOI":"10.1084\/jem.190.3.385"},{"key":"bibr11-0960327119891224","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510310220"},{"key":"bibr12-0960327119891224","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00267-1"},{"key":"bibr13-0960327119891224","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3780131"},{"issue":"3","key":"bibr14-0960327119891224","first-page":"310","volume":"49","author":"Beutler E","year":"1976","journal-title":"Yale J Biol Med"},{"key":"bibr15-0960327119891224","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(86)90247-0"},{"key":"bibr16-0960327119891224","first-page":"189","volume":"24","author":"Lorentz K","year":"1986","journal-title":"J Clin Chem Clin Biochem"},{"key":"bibr17-0960327119891224","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)05016-3"},{"key":"bibr18-0960327119891224","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(86)90286-3"},{"key":"bibr19-0960327119891224","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(57)90149-7"},{"key":"bibr20-0960327119891224","first-page":"4443","volume":"51","author":"Wei H","year":"1991","journal-title":"Cancer Res"},{"key":"bibr21-0960327119891224","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"bibr22-0960327119891224","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2012.12.004"},{"key":"bibr23-0960327119891224","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2017.10.085"},{"key":"bibr24-0960327119891224","volume-title":"Gastrointestinal disease, pathophysiology, diagnosis and management","author":"Cello JP","year":"1989"},{"key":"bibr25-0960327119891224","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033510"},{"key":"bibr26-0960327119891224","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(200005)30:5<1331::AID-IMMU1331>3.0.CO;2-H"},{"key":"bibr27-0960327119891224","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201900017R"},{"key":"bibr28-0960327119891224","doi-asserted-by":"publisher","DOI":"10.3892\/or.2010.869"},{"key":"bibr29-0960327119891224","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70259-8"},{"key":"bibr30-0960327119891224","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4889(96)00031-6"},{"key":"bibr31-0960327119891224","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2004-0084"},{"key":"bibr32-0960327119891224","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M209673200"},{"key":"bibr33-0960327119891224","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/10.6.559"},{"issue":"1","key":"bibr34-0960327119891224","first-page":"103","volume":"43","author":"Jiang ZJ","year":"2019","journal-title":"Int J Mol Med"},{"key":"bibr35-0960327119891224","first-page":"56","volume":"30","author":"Murata Y","year":"1995","journal-title":"J Gastroenterol"},{"key":"bibr36-0960327119891224","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-006-9597-z"},{"key":"bibr37-0960327119891224","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1999.00878.x"},{"key":"bibr38-0960327119891224","doi-asserted-by":"publisher","DOI":"10.1039\/C5FO01228G"},{"key":"bibr39-0960327119891224","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)92831-2"},{"key":"bibr40-0960327119891224","doi-asserted-by":"publisher","DOI":"10.1080\/10408399509527682"},{"key":"bibr41-0960327119891224","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2012.03.001"},{"key":"bibr42-0960327119891224","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2016.0020"},{"key":"bibr43-0960327119891224","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.1999.00485.x"},{"key":"bibr44-0960327119891224","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2008.06.002"}],"container-title":["Human &amp; Experimental Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0960327119891224","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0960327119891224","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0960327119891224","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:49:17Z","timestamp":1777448957000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0960327119891224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,1]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1177\/0960327119891224"],"URL":"https:\/\/doi.org\/10.1177\/0960327119891224","relation":{},"ISSN":["0960-3271","1477-0903"],"issn-type":[{"value":"0960-3271","type":"print"},{"value":"1477-0903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,1]]}}}