{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T15:34:41Z","timestamp":1789140881104,"version":"build-2803163510"},"reference-count":27,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T00:00:00Z","timestamp":1576022400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7162089"],"award-info":[{"award-number":["7162089"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Epirubicin is a potent chemotherapeutic agent for the treatment of breast cancer. However, it may lead to cardiotoxicity and cardiomyopathy, and no reliable biomarker was available for the early prediction of epirubicin-induced cardiomyopathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Global gene expression changes of peripheral blood cells were studied using high-throughput RNA sequencing in three pair-matched breast cancer patients (patients who developed symptomatic cardiomyopathy paired with patients who did not) before and after the full session of epirubicin-based chemotherapy. Functional analysis was conducted using gene ontology and pathway enrichment analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We identified 13 significantly differentially expressed genes between patients who developed symptomatic epirubicin-induced cardiomyopathy and their paired control who did not. Among them, the upregulated Bcl-associated X protein was related to \u201capoptosis,\u201d while the downregulated 5\u2032-aminolevulinate synthase 2 (ALAS2) was related to both \u201cglycine, serine, and threonine metabolism\u201d and \u201cporphyrin and chlorophyll metabolism\u201d in pathway enrichment analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>ALAS2 and the metabolic pathways which were involved may play an important role in the development of epirubicin-induced cardiomyopathy. ALAS2 may be useful as an early biomarker for epirubicin-induced cardiotoxicity detection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0960327119893415","type":"journal-article","created":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T06:46:14Z","timestamp":1576046774000},"page":"393-401","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Identification of differential gene expression related to epirubicin-induced cardiomyopathy in breast cancer patients"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0068-8728","authenticated-orcid":false,"given":"J","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Cardiology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China"},{"name":"*Both the authors contributed equally to this work."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China"},{"name":"*Both the authors contributed equally to this work."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, 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