{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T05:05:42Z","timestamp":1788930342540,"version":"build-2803163510"},"reference-count":25,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T00:00:00Z","timestamp":1578873600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Chonnam National University Hospital Biomedical Research Institute.","award":["CR 18031-1"],"award-info":[{"award-number":["CR 18031-1"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:p>\n                    The objective was to describe the prevalence of derangement of the partial pressure of arterial carbon dioxide (PaCO\n                    <jats:sub>2<\/jats:sub>\n                    ) and to determine the association between PaCO\n                    <jats:sub>2<\/jats:sub>\n                    and adverse cardiovascular events (ACVEs) in carbon monoxide (CO)-poisoned patients. Additionally, we evaluated whether the derangement of PaCO\n                    <jats:sub>2<\/jats:sub>\n                    was simply secondary to metabolic changes. This retrospective study included 194 self-breathing patients after CO poisoning with an indication for hyperbaric oxygen therapy and available arterial blood gas analysis at presentation and 6 h later. The incidence rate of hypocapnia at presentation after acute CO poisoning was 67.5%, and the mean PaCO\n                    <jats:sub>2<\/jats:sub>\n                    during the first 6 h was 33 (31\u201336.7) mmHg. The most common acid\u2013base imbalance in 131 patients with hypocapnia was primary respiratory alkalosis. The incidence rate of ACVEs during hospitalization was 50.5%. A significant linear trend in the incidence of ACVEs was observed across the total range of PaCO\n                    <jats:sub>2<\/jats:sub>\n                    variables. In multivariate regression analysis, mean PaCO\n                    <jats:sub>2<\/jats:sub>\n                    was independently associated with ACVEs (odds ratio 0.051; 95% confidence interval 0.004\u20130.632). PaCO\n                    <jats:sub>2<\/jats:sub>\n                    derangements were common after acute CO poisoning and were not explainable as a mere secondary response to metabolic changes. The mean PaCO\n                    <jats:sub>2<\/jats:sub>\n                    during the first 6 h was associated with ACVEs. Given the high incidence of ACVEs and PaCO\n                    <jats:sub>2<\/jats:sub>\n                    derangement and the observed association between the mean PaCO\n                    <jats:sub>2<\/jats:sub>\n                    and ACVEs, this study suggests that (1) PaCO\n                    <jats:sub>2<\/jats:sub>\n                    should be monitored in the acute stage to predict and\/or prevent ACVEs and (2) further investigation is needed to validate this result and explore the early manipulation of PaCO\n                    <jats:sub>2<\/jats:sub>\n                    as a treatment strategy.\n                  <\/jats:p>","DOI":"10.1177\/0960327119898720","type":"journal-article","created":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T08:17:44Z","timestamp":1578903464000},"page":"642-652","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Derangement of PaCO\n                    <sub>2<\/sub>\n                    requires physician attention in acute carbon monoxide poisoning"],"prefix":"10.1177","volume":"39","author":[{"given":"JM","family":"Moon","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Chonnam National University Medical School, Gwangju, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5240-4213","authenticated-orcid":false,"given":"BJ","family":"Chun","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Chonnam National University Medical School, Gwangju, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YS","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Chonnam National University Medical School, Gwangju, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,1,13]]},"reference":[{"key":"bibr1-0960327119898720","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2012.06.004"},{"key":"bibr2-0960327119898720","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2009.04.006"},{"key":"bibr3-0960327119898720","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.4.398"},{"key":"bibr4-0960327119898720","doi-asserted-by":"publisher","DOI":"10.1097\/MEJ.0b013e328320ad48"},{"key":"bibr5-0960327119898720","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000000820"},{"key":"bibr6-0960327119898720","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000269209.53450.EC"},{"key":"bibr7-0960327119898720","doi-asserted-by":"publisher","DOI":"10.1191\/0960327106het645oa"},{"key":"bibr8-0960327119898720","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1966.21.3.848"},{"issue":"2","key":"bibr9-0960327119898720","first-page":"107","volume":"24","author":"Jiang J","year":"1997","journal-title":"Undersea Hyperb Med"},{"key":"bibr10-0960327119898720","doi-asserted-by":"publisher","DOI":"10.1007\/s12012-018-09501-w"},{"key":"bibr11-0960327119898720","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.03990"},{"key":"bibr12-0960327119898720","doi-asserted-by":"publisher","DOI":"10.1007\/s13181-010-0074-x"},{"key":"bibr13-0960327119898720","doi-asserted-by":"publisher","DOI":"10.1186\/1757-1626-1-102"},{"issue":"8","key":"bibr14-0960327119898720","first-page":"BC01","volume":"10","author":"Ghatak I","year":"2016","journal-title":"J Clin Diagn Res"},{"key":"bibr15-0960327119898720","doi-asserted-by":"publisher","DOI":"10.4103\/0972-5229.68215"},{"key":"bibr16-0960327119898720","doi-asserted-by":"publisher","DOI":"10.1007\/s12012-017-9418-y"},{"key":"bibr17-0960327119898720","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2018.09.005"},{"issue":"3","key":"bibr18-0960327119898720","first-page":"185","volume":"50","author":"Hajsadeghi S","year":"2012","journal-title":"Acta Med Iran"},{"key":"bibr19-0960327119898720","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/9.2.167"},{"key":"bibr20-0960327119898720","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.2.2003039"},{"key":"bibr21-0960327119898720","first-page":"1188","volume":"93","author":"Sasano H","year":"2001","journal-title":"AnesthAnalg"},{"key":"bibr22-0960327119898720","doi-asserted-by":"publisher","DOI":"10.1136\/emj.16.2.96"},{"key":"bibr23-0960327119898720","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31818419d8"},{"key":"bibr24-0960327119898720","doi-asserted-by":"publisher","DOI":"10.1002\/9780470715352.ch10"},{"key":"bibr25-0960327119898720","doi-asserted-by":"publisher","DOI":"10.1177\/147323001204000138"}],"container-title":["Human &amp; 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