{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:45:18Z","timestamp":1777668318829,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T00:00:00Z","timestamp":1587686400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Quercetin exerts anti-inflammatory effects, but whether it can benefit patients with the chronic inflammatory disease of oral lichen planus (OLP), which is a common chronic mucocutaneous disorder with an immune-mediated pathogenesis, is unclear. The present research examined the impacts of quercetin in a cell-based OLP model in which human oral keratinocytes (HOKs) were treated with lipopolysaccharide (LPS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Effects of quercetin on viability, proliferation, and apoptosis of HOKs were assessed using the Cell Counting Kit-8 assay, Western blotting, and flow cytometry, respectively. Effects of treatment on levels of microRNA-22 (miR-22) were measured using stem-loop reverse transcription polymerase chain reaction, while levels of proteins and phosphorylation in the PI3K\/AKT and JAK1\/STAT3 cascades were analyzed by Western blot.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Quercetin mitigated LPS-induced reduction in HOK viability and elevation of apoptosis. It also weakened LPS-induced upregulation of miR-22. Quercetin treatment led to significantly higher levels of p-PI3K, p-AKT, p-JAK1, and p-STAT3. These effects of quercetin were enhanced when miR-22 was knocked down and partly reversed when miR-22 was overexpressed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Quercetin can mitigate LPS-induced injury in HOKs by downregulating miR-22, thereby activating PI3K\/AKT and JAK1\/STAT3 cascades.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0960327120918291","type":"journal-article","created":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T06:33:50Z","timestamp":1587710030000},"page":"1310-1317","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Quercetin protects human oral keratinocytes from lipopolysaccharide-induced injury by downregulating microRNA-22"],"prefix":"10.1177","volume":"39","author":[{"given":"F","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Stomatology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Ke","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7623-6253","authenticated-orcid":false,"given":"FJ","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,4,24]]},"reference":[{"key":"bibr1-0960327120918291","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2014.01.001"},{"key":"bibr2-0960327120918291","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.05.076"},{"key":"bibr3-0960327120918291","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2016.05.004"},{"key":"bibr4-0960327120918291","first-page":"28","volume":"74","author":"Gorouhi F","year":"2014","journal-title":"Scientific World J"},{"key":"bibr5-0960327120918291","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2016.03.018"},{"key":"bibr6-0960327120918291","first-page":"316","volume":"14","author":"Ahmadi-Motamayel F","year":"2017","journal-title":"Iran J Immunol"},{"key":"bibr7-0960327120918291","doi-asserted-by":"publisher","DOI":"10.15171\/joddd.2015.005"},{"key":"bibr8-0960327120918291","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.104346"},{"key":"bibr9-0960327120918291","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-014-2317-7"},{"key":"bibr10-0960327120918291","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2012.07.045"},{"key":"bibr11-0960327120918291","first-page":"701","volume":"14","author":"Lu R","year":"2014","journal-title":"Mediators Inflamm"},{"key":"bibr12-0960327120918291","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2010.00946.x"},{"key":"bibr13-0960327120918291","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2004.05.015"},{"key":"bibr14-0960327120918291","first-page":"142","volume":"8","author":"Li Z","year":"2016","journal-title":"Am J Transl Res"},{"key":"bibr15-0960327120918291","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.11660"},{"key":"bibr16-0960327120918291","doi-asserted-by":"publisher","DOI":"10.1159\/000494624"},{"key":"bibr17-0960327120918291","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2018.08.004"},{"key":"bibr18-0960327120918291","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0192009"},{"key":"bibr19-0960327120918291","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-8-102"},{"key":"bibr20-0960327120918291","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.02.043"},{"key":"bibr21-0960327120918291","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.05.042"},{"key":"bibr22-0960327120918291","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-10-79"},{"key":"bibr23-0960327120918291","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.03.055"},{"key":"bibr24-0960327120918291","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphs.2019.03.005"}],"container-title":["Human &amp; 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