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Its structural and pharmacological comparabilities to clonidine give way to the hypothesis that it may cause neuropsychiatric side effects. The majority of case reports citing brimonidine toxicity, either for topical or peripheral exposure, include pediatric age groups but especially infants. Among the latter, a dose-response phenomenon is evident. Dose-response correlates have also been shown among adults. Case series and prospective double-blind treatment studies also give evidence for the occurrence of several central nervous system adverse reactions. Topical ophthalmic brimonidine use should be followed for the occurrence of neuropsychiatric disturbances generally, and enhanced vigilance should be maintained for at-risk populations.<\/jats:p>","DOI":"10.1177\/0960327120918307","type":"journal-article","created":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T07:23:12Z","timestamp":1588144992000},"page":"1279-1290","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["A review of neuropsychiatric adverse events from topical ophthalmic brimonidine"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2743-0556","authenticated-orcid":false,"given":"N","family":"Cimolai","sequence":"first","affiliation":[{"name":"Faculty of Medicine, The University of British Columbia, Vancouver, BC, Canada"},{"name":"Children\u2019s and Women\u2019s Health Centre of British Columbia, Vancouver, BC, 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