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Thus, there is a growing effort to identify compounds that can ameliorate NPs-associated pathophysiologies. The present study examined Cinnamomum cassia ( C. cassia) bark extracts (CMBE) for its ameliorative activity against Ni-NPs-induced pathophysiological and histopathological alterations in male Sprague Dawley rats. The biochemical analyses revealed that dosing rats with Ni-NPs at 10 mg\/kg\/body weight (b.w.) significantly altered the normal structural and biochemical adaptations in the liver and kidney. Conversely, supplementations with CMBE at different doses (225, 200, and 175 mg\/kg\/b.w. of rat) ameliorated the altered blood biochemistry and reduced the biomarkers of liver and kidney function considerably ( p &lt; 0.05) in a dose-dependent manner. However, the best results were at 225 mg\/kg\/b.w. of rat. The study provided preliminary information about the protective effect of C. cassia against Ni-NPs indicated liver and kidney damages. Future investigations are needed to explore C. cassia mechanism of action and isolation of single constituents of C. cassia to assess their pharmaceutical importance accordingly.<\/jats:p>","DOI":"10.1177\/0960327120930125","type":"journal-article","created":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T06:45:14Z","timestamp":1592894714000},"page":"1565-1581","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["<i>Cinnamomum cassia<\/i>\n                    ameliorates Ni-NPs-induced liver and kidney damage in male Sprague Dawley rats"],"prefix":"10.1177","volume":"39","author":[{"given":"S","family":"Iqbal","sequence":"first","affiliation":[{"name":"Department of Zoology, Government College University Faisalabad, Faisalabad, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Jabeen","sequence":"additional","affiliation":[{"name":"Department of Zoology, Government College University Faisalabad, Faisalabad, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Peng","sequence":"additional","affiliation":[{"name":"Queensland Alliance for Environmental Health Sciences, The University of Queensland, Woolloongabba, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MU","family":"Ijaz","sequence":"additional","affiliation":[{"name":"Department of Zoology, Wildlife and Fisheries, University of Agriculture, Faisalabad, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AS","family":"Chaudhry","sequence":"additional","affiliation":[{"name":"School of Natural and Environmental Science, Newcastle University, Newcastle upon Tyne, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,6,23]]},"reference":[{"key":"bibr1-0960327120930125","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2003.09.009"},{"key":"bibr2-0960327120930125","doi-asserted-by":"publisher","DOI":"10.1039\/C4CS00177J"},{"key":"bibr3-0960327120930125","doi-asserted-by":"publisher","DOI":"10.1080\/17425247.2016.1182487"},{"key":"bibr4-0960327120930125","doi-asserted-by":"publisher","DOI":"10.21010\/ajtcam.v13i4.28"},{"key":"bibr5-0960327120930125","first-page":"226","volume":"5","author":"Lee HS","year":"2002","journal-title":"J Pharm Pharm Sci"},{"key":"bibr6-0960327120930125","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1190"},{"key":"bibr7-0960327120930125","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087894"},{"key":"bibr8-0960327120930125","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5614564"},{"key":"bibr9-0960327120930125","doi-asserted-by":"publisher","DOI":"10.4314\/ajtcam.v11i4.1"},{"key":"bibr10-0960327120930125","first-page":"654","volume":"10","author":"Sivaraj C","year":"2015","journal-title":"Am J Phytomed Clin Ther"},{"key":"bibr11-0960327120930125","first-page":"1346","volume":"23","author":"Ervina M","year":"2016","journal-title":"Int Food Res J"},{"key":"bibr12-0960327120930125","doi-asserted-by":"publisher","DOI":"10.1039\/C5FO00569H"},{"key":"bibr13-0960327120930125","first-page":"495","volume":"11","author":"Eidi A","year":"2012","journal-title":"Excli J"},{"key":"bibr14-0960327120930125","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-017-1074-3"},{"key":"bibr15-0960327120930125","doi-asserted-by":"publisher","DOI":"10.3390\/ijms151121253"},{"key":"bibr16-0960327120930125","volume-title":"Extraction technologies for medicinal and aromatic plants","author":"Handa SS","year":"2008","edition":"1"},{"key":"bibr17-0960327120930125","volume-title":"Assessment report on Cinnamomum verum J.S. 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