{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T15:14:54Z","timestamp":1786720494398,"version":"build-2736575974"},"reference-count":64,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T00:00:00Z","timestamp":1593475200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:p>Monoterpenes present in the essential oils exhibit anti-inflammatory properties. In this study, we investigated the preventive effect of alpha-pinene (AP), a monoterpene, against isoproterenol (ISO)-induced myocardial infarction and inflammation in Wistar rats. Male Wistar rats were pretreated with AP (50 mg\/kg body weight (bw)) administration for 21 days and ISO (85 mg\/kg bw) was administered subcutaneously for last two consecutive days (20th day and 21st day). We noticed that there was an increased activity of cardiac marker enzymes in ISO-treated rats. We also observed that elevated levels of lipid peroxidative indices decreased activities of antioxidant status in plasma, erythrocyte, and heart tissue in ISO-induced rats. Furthermore, ISO-treated rats showed an increase in the levels of inflammatory mediators like tumor necrosis factor-\u03b1 (TNF-\u03b1) and interleukin-6 (IL-6) in the serum. Besides, we confirmed the upregulated expression of TNF-\u03b1, IL-6, and nuclear factor kappa-light-chain-enhancer of activated B cells in ISO-induced rat heart tissue. Conversely, we found that AP pretreatment significantly decreased levels of cardiac markers like serum cardiac troponin T and cardiac troponin I, lipid peroxidative markers, and restored antioxidants status in ISO-treated rats. Besides, AP administration attenuated ISO-induced inflammatory marker expression. The present findings demonstrated that AP significantly protects the myocardium and exerts cardioprotective and anti-inflammatory effects in experimental rats.<\/jats:p>","DOI":"10.1177\/0960327120934537","type":"journal-article","created":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T06:59:36Z","timestamp":1593500376000},"page":"1596-1606","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":46,"title":["Protective effect of alpha-pinene against isoproterenol-induced myocardial infarction through NF-\u03baB signaling pathway"],"prefix":"10.1177","volume":"39","author":[{"given":"B","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Health Care Center, Beijing Friendship Hospital Medical, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The 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