{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:46:54Z","timestamp":1777668414934,"version":"3.51.4"},"reference-count":95,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T00:00:00Z","timestamp":1597795200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:p>\n                    In this study, both diabetes and Dunning prostate cancer were induced for the first time in Copenhagen rats in vivo. Thus, the effects of metformin against heart tissue damage of these rats were investigated by biochemical methods. Dunning prostate cancer was induced in Copenhagen rats using high metastatic MAT-LyLu cells. The rats were divided as follows: Control group: only injected with 0.9% NaCl for 14 days; Diabetic group: only injected single dose of streptozotocin (STZ) (65 mg\/kg); Cancer group: subcutaneously (s.c) inoculated with 2 x 10\n                    <jats:sup>4<\/jats:sup>\n                    MAT-LyLu cells only; Diabetic + cancer (DC) group: inoculated with 2 x 10\n                    <jats:sup>4<\/jats:sup>\n                    MAT-LyLu cells and STZ injection, Cancer + metformin (CM) group: injected with metformin for 14 days after Mat-LyLu cells application; Diabetic + cancer + metformin (DCM) group: metformin administered for 14 days together with STZ and Mat-LyLu cells. At the end of the experimental period, heart tissues were taken. Reduced glutathione and total antioxidant status levels in heart tissues were decreased, whereas lipid peroxidation, advanced oxidized protein products, nitric oxide, homocysteine, and reactive oxygen species levels, total oxidant status and catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase, glutathione-S-transferase, alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase and xanthine oxidase activities increased in the diabetic, cancer and DC groups. Treatment with metformin reversed these effects. In conclusion, the present study shows that metformin has a protective effect against heart tissue damage in STZ-induced diabetic rats with Dunning prostate cancer.\n                  <\/jats:p>","DOI":"10.1177\/0960327120947452","type":"journal-article","created":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T05:37:56Z","timestamp":1597815476000},"page":"297-309","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Metformin protects against diabetes-induced heart injury and dunning prostate cancer model"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0700-5096","authenticated-orcid":false,"given":"BB","family":"Bayrak","sequence":"first","affiliation":[{"name":"Faculty of Engineering, Department of Chemistry, Istanbul University-Cerrahpasa, Avcilar, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3408-7867","authenticated-orcid":false,"given":"P","family":"Koroglu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Division of Histology and Embryology, Halic University, Beyoglu, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O","family":"Karabulut Bulan","sequence":"additional","affiliation":[{"name":"Faculty of Science, Department of Biology, Istanbul University, Vezneciler, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Yanardag","sequence":"additional","affiliation":[{"name":"Faculty of Engineering, Department of Chemistry, Istanbul University-Cerrahpasa, Avcilar, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,8,19]]},"reference":[{"key":"bibr1-0960327120947452","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21551"},{"key":"bibr2-0960327120947452","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21590"},{"key":"bibr3-0960327120947452","doi-asserted-by":"publisher","DOI":"10.14740\/wjon1191"},{"key":"bibr4-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2019.102861"},{"key":"bibr5-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2019.06.015"},{"key":"bibr6-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/5202684"},{"key":"bibr7-0960327120947452","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2017.04.41"},{"key":"bibr8-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2019.04.009"},{"key":"bibr9-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2019-000872"},{"key":"bibr10-0960327120947452","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2017.591"},{"key":"bibr11-0960327120947452","first-page":"1","volume":"26","author":"Mohamed HE","year":"2020","journal-title":"Zagazig University Med J"},{"key":"bibr12-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2018.10.015"},{"key":"bibr13-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2018.03.099"},{"key":"bibr14-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.311371"},{"key":"bibr15-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2017.19"},{"key":"bibr16-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.223545"},{"key":"bibr17-0960327120947452","doi-asserted-by":"publisher","DOI":"10.3390\/ijms161025234"},{"key":"bibr18-0960327120947452","doi-asserted-by":"publisher","DOI":"10.3390\/nu11122850"},{"key":"bibr19-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz766"},{"key":"bibr20-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29210"},{"key":"bibr21-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2013.256"},{"key":"bibr22-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-15-0447"},{"key":"bibr23-0960327120947452","doi-asserted-by":"crossref","first-page":"e0036","DOI":"10.1097\/MD.0000000000010036","volume":"97","author":"Kim HJ","year":"2018","journal-title":"Medicine"},{"key":"bibr24-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.2025"},{"key":"bibr25-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0000000000000514"},{"key":"bibr26-0960327120947452","doi-asserted-by":"crossref","volume-title":"Preventive and (neo) adjuvant therapeutic effects of metformin on cancer","author":"Jiao Y","DOI":"10.5772\/intechopen.91291"},{"key":"bibr27-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(95)00772-2"},{"key":"bibr28-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.12484"},{"key":"bibr29-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0107220"},{"key":"bibr30-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/231378"},{"key":"bibr31-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-0108"},{"key":"bibr32-0960327120947452","unstructured":"Beutler E. Glutathione in red cell metabolism: a manual of biochemical methods. 2nd edn. New York, NY: Grune and Stratton, 1975, pp. 112\u2013114."},{"key":"bibr33-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(86)90247-0"},{"key":"bibr34-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1996.186"},{"key":"bibr35-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1006\/niox.2000.0319"},{"key":"bibr36-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-018-2414-3"},{"key":"bibr37-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2005.08.008"},{"key":"bibr38-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2003.11.015"},{"key":"bibr39-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)05016-3"},{"key":"bibr40-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(86)90286-3"},{"key":"bibr41-0960327120947452","first-page":"158","volume":"70","author":"Paglia DE","year":"1967","journal-title":"J Lab Clin Med"},{"key":"bibr42-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(81)77046-0"},{"key":"bibr43-0960327120947452","unstructured":"Beutler E. Red cell metabolism. A manual of biochemical methods. Vol. 12. London: Academic Press, 1971, pp. 68\u201370."},{"key":"bibr44-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(81)77053-8"},{"key":"bibr45-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/28.1.56"},{"key":"bibr46-0960327120947452","first-page":"639","volume":"32","author":"Bais R","year":"1994","journal-title":"Eur J Clin Chem Clin Biochem"},{"key":"bibr47-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1042\/bj1080349"},{"key":"bibr48-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"bibr49-0960327120947452","first-page":"69","volume":"63","author":"Singh RK","year":"2019","journal-title":"J Sci Res Banaras Hindu University"},{"key":"bibr50-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-019-04991-x"},{"key":"bibr51-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1097\/WOX.0b013e3182439613"},{"key":"bibr52-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201804161"},{"key":"bibr53-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-020-05292-y"},{"key":"bibr54-0960327120947452","doi-asserted-by":"publisher","DOI":"10.31557\/APJCP.2018.19.12.3511"},{"key":"bibr55-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.02.088"},{"key":"bibr56-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1556\/036.102.2015.4.5"},{"key":"bibr57-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2019.e02935"},{"key":"bibr58-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1038\/s41391-018-0085-2"},{"key":"bibr59-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1097\/CAD.0000000000000870"},{"key":"bibr60-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1007\/s12012-016-9377-8"},{"key":"bibr61-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2007.1999"},{"key":"bibr62-0960327120947452","doi-asserted-by":"publisher","DOI":"10.2174\/2211738507666190429111306"},{"key":"bibr63-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-11-118"},{"key":"bibr64-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1177\/1178223419882688"},{"key":"bibr65-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.16.1933"},{"key":"bibr66-0960327120947452","doi-asserted-by":"publisher","DOI":"10.5507\/bp.2005.009"},{"key":"bibr67-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(03)00499-4"},{"key":"bibr68-0960327120947452","first-page":"708","volume":"5","author":"Beyramzadeh M","year":"2017","journal-title":"J Pharm Pharmacol"},{"key":"bibr69-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2008.04920.x"},{"key":"bibr70-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/424813"},{"key":"bibr71-0960327120947452","doi-asserted-by":"publisher","DOI":"10.21601\/ortadogutipdergisi.462457"},{"key":"bibr72-0960327120947452","author":"Zhong GC","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"bibr73-0960327120947452","doi-asserted-by":"publisher","DOI":"10.3390\/biom9100637"},{"key":"bibr74-0960327120947452","doi-asserted-by":"crossref","first-page":"362","DOI":"10.17343\/sdutfd.566969","volume":"26","author":"Aslanko\u00e7 R","year":"2019","journal-title":"Med J SDU"},{"key":"bibr75-0960327120947452","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics10030126"},{"key":"bibr76-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1007\/s005920070012"},{"key":"bibr77-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0067009"},{"key":"bibr78-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/4907648"},{"key":"bibr79-0960327120947452","first-page":"244","volume":"30","author":"Kotrikadze N","year":"2008","journal-title":"Exp Oncol"},{"key":"bibr80-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1186\/2251-6581-11-3"},{"key":"bibr81-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/614579"},{"key":"bibr82-0960327120947452","doi-asserted-by":"crossref","first-page":"6978625","DOI":"10.1155\/2016\/6978625","volume":"2016","author":"Vilela DD","year":"2016","journal-title":"Oxid Med Cell Longev"},{"key":"bibr83-0960327120947452","first-page":"251","volume":"42","author":"Volkovova K","year":"1993","journal-title":"Physiol Res"},{"key":"bibr84-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2013.11.008"},{"key":"bibr85-0960327120947452","first-page":"817","volume":"15","author":"McGill MR","year":"2016","journal-title":"EXCLI J"},{"key":"bibr86-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114517000174"},{"key":"bibr87-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1007\/s10616-013-9563-5"},{"key":"bibr88-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1191\/0960327104ht507oa"},{"key":"bibr89-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-290-2_7"},{"key":"bibr90-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066776"},{"key":"bibr91-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.016379"},{"key":"bibr92-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000041431.57222.AF"},{"key":"bibr93-0960327120947452","first-page":"658","volume":"6","author":"Farshid AA","year":"2016","journal-title":"Avicenna J Phytomed"},{"key":"bibr94-0960327120947452","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2143(03)00110-0"},{"key":"bibr95-0960327120947452","first-page":"818","volume":"38","author":"Cosi\u0107 V","year":"2001","journal-title":"Clin Chem Lab Med"}],"container-title":["Human &amp; Experimental Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0960327120947452","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0960327120947452","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0960327120947452","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:49:57Z","timestamp":1777448997000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0960327120947452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,19]]},"references-count":95,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1177\/0960327120947452"],"URL":"https:\/\/doi.org\/10.1177\/0960327120947452","relation":{},"ISSN":["0960-3271","1477-0903"],"issn-type":[{"value":"0960-3271","type":"print"},{"value":"1477-0903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,19]]}}}