{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:37:25Z","timestamp":1790023045359,"version":"4.0.1"},"reference-count":46,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T00:00:00Z","timestamp":1597276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"University Grants Commission, New Delhi","award":["a non-NET fellowship to Rajesh Prasad"],"award-info":[{"award-number":["a non-NET fellowship to Rajesh Prasad"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:p>Cisplatin is an effective anticancer drug used against a variety of cancers. The full therapeutic potential of cisplatin is often hampered due to concurrent development of various side effects in the hosts. Rutin, a naturally occurring bioflavonoid shows several pharmacological activities. It has been earlier reported by us that rutin and cisplatin in combination show better antitumor activity against murine ascites Dalton\u2019s lymphoma. As cisplatin is given to cancer-bearing hosts only, the present study was undertaken to explore the histoprotective effect of rutin against some toxicities induced by cisplatin in tumor-bearing mice. Cisplatin treatment caused severe damages in tissue architecture such as degenerated hepatocytes with nuclear condensation and sinusoidal dilatation in the liver, glomerular deterioration, infiltration of cells, and tubular congestion in the kidney, and vacuolization of Sertoli cells or dense granules in the cytoplasm and damaged seminiferous tubules in the testes. In the rutin plus cisplatin combination-treated mice, all the abnormal tissue architectural features were decreased. Further, as compared to cisplatin treatment, combination treatment did not show any significant elevation in the liver functional biomarkers (serum aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase) and renal functional biomarkers (serum urea and creatinine levels). The combination treatment reduced the sperm abnormalities also as compared to the cisplatin alone treatment. The in vitro hemolysis assay of red blood cells and scanning electron microscopy revealed that combination treatment lessened the cisplatin-induced hemolysis and abnormalities in RBCs. Thus, the present findings demonstrate that rutin has histoprotective ability against cisplatin-induced toxicities in tumor-bearing mice.<\/jats:p>","DOI":"10.1177\/0960327120947793","type":"journal-article","created":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T04:10:03Z","timestamp":1597291803000},"page":"245-258","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Histoprotective effect of rutin against cisplatin-induced toxicities in tumor-bearing mice: Rutin lessens cisplatin-induced toxicities"],"prefix":"10.1177","volume":"40","author":[{"given":"R","family":"Prasad","sequence":"first","affiliation":[{"name":"Cell and Tumor Biology Laboratory, Department of Zoology, School of Life Sciences, North-Eastern Hill University, Shillong, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8578-8789","authenticated-orcid":false,"given":"SB","family":"Prasad","sequence":"additional","affiliation":[{"name":"Cell and Tumor Biology Laboratory, Department of Zoology, School of Life Sciences, North-Eastern Hill University, Shillong, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,8,13]]},"reference":[{"key":"bibr1-0960327120947793","unstructured":"Cancer Facts & Figures\u00a02018. American Cancer Society, Atlanta, USA, https:\/\/www.cancer.org\/content\/dam\/cancer-org\/research\/cancer-facts-andstatistics\/annual-cancer-facts-and-figures\/2018\/cancer-facts-and-figures-2018.pdf (2018, accessed on 12 March 2020)."},{"key":"bibr2-0960327120947793","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2014.07.025"},{"key":"bibr3-0960327120947793","doi-asserted-by":"publisher","DOI":"10.1039\/C8DT00838H"},{"key":"bibr4-0960327120947793","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70064-6"},{"key":"bibr5-0960327120947793","doi-asserted-by":"publisher","DOI":"10.3109\/01480545.2014.992437"},{"key":"bibr6-0960327120947793","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-017-3358-x"},{"key":"bibr7-0960327120947793","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.01.180"},{"key":"bibr8-0960327120947793","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-017-2981-5"},{"key":"bibr9-0960327120947793","doi-asserted-by":"publisher","DOI":"10.3390\/nu9020166"},{"key":"bibr10-0960327120947793","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-017-0601-y"},{"key":"bibr11-0960327120947793","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3841.2010.02033.x"},{"key":"bibr12-0960327120947793","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2011.02.059"},{"key":"bibr13-0960327120947793","doi-asserted-by":"publisher","DOI":"10.36468\/pharmaceutical-sciences.563"},{"key":"bibr14-0960327120947793","doi-asserted-by":"publisher","DOI":"10.31024\/ajpp.2019.5.s1.1"},{"key":"bibr15-0960327120947793","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2017.05.026"},{"key":"bibr16-0960327120947793","doi-asserted-by":"publisher","DOI":"10.3923\/ijp.2017.516.528"},{"key":"bibr17-0960327120947793","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-018-1195-9"},{"key":"bibr18-0960327120947793","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-018-0550-5"},{"key":"bibr19-0960327120947793","doi-asserted-by":"publisher","DOI":"10.3923\/ijp.2018.39.51"},{"key":"bibr20-0960327120947793","first-page":"42","volume":"4","author":"Prasad R","year":"2018","journal-title":"Res J Life Sci Bioinform Pharmaceut Chem Sci"},{"key":"bibr21-0960327120947793","doi-asserted-by":"publisher","DOI":"10.1007\/s12639-015-0744-3"},{"key":"bibr22-0960327120947793","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2015.01.017"},{"key":"bibr23-0960327120947793","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.72.11.4425"},{"key":"bibr24-0960327120947793","first-page":"112","volume":"52","author":"Kalita S","year":"2014","journal-title":"Indian J Exp Biol"},{"key":"bibr25-0960327120947793","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.10.178"},{"key":"bibr26-0960327120947793","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0134139"},{"key":"bibr27-0960327120947793","first-page":"1870","volume":"5","author":"Lonchar A","year":"2016","journal-title":"World J Pharm Pharmaceut Sci"},{"key":"bibr28-0960327120947793","first-page":"57","volume":"8","author":"Akondi RB","year":"2011","journal-title":"Eur J Gen Med"},{"key":"bibr29-0960327120947793","doi-asserted-by":"publisher","DOI":"10.3109\/15569543.2016.1155623"},{"key":"bibr30-0960327120947793","doi-asserted-by":"publisher","DOI":"10.1016\/j.apjtb.2017.06.013"},{"key":"bibr31-0960327120947793","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-12-178"},{"key":"bibr32-0960327120947793","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.21567"},{"key":"bibr33-0960327120947793","first-page":"352","volume":"4","author":"Ashraf J","year":"2012","journal-title":"Int J Drug Dev Res"},{"key":"bibr34-0960327120947793","doi-asserted-by":"publisher","DOI":"10.14202\/vetworld.2017.74-80"},{"key":"bibr35-0960327120947793","first-page":"395","volume":"51","author":"Horv\u00e1thov\u00e1 K","year":"2004","journal-title":"Neoplasma"},{"key":"bibr36-0960327120947793","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2011.05.012"},{"key":"bibr37-0960327120947793","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2013.815546"},{"key":"bibr38-0960327120947793","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2015.1006100"},{"key":"bibr39-0960327120947793","first-page":"116","volume":"3","author":"Umarani V","year":"2015","journal-title":"Int J Adv Pharm Med Bioallied Sci"},{"key":"bibr40-0960327120947793","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.11.110"},{"key":"bibr41-0960327120947793","doi-asserted-by":"publisher","DOI":"10.1186\/s12894-018-0421-9"},{"key":"bibr42-0960327120947793","doi-asserted-by":"publisher","DOI":"10.1111\/and.12593"},{"key":"bibr43-0960327120947793","doi-asserted-by":"publisher","DOI":"10.4103\/0971-6580.97224"},{"key":"bibr44-0960327120947793","doi-asserted-by":"publisher","DOI":"10.3109\/15569543.2015.1136333"},{"key":"bibr45-0960327120947793","doi-asserted-by":"publisher","DOI":"10.1111\/and.12696"},{"key":"bibr46-0960327120947793","doi-asserted-by":"publisher","DOI":"10.5812\/ircmj.44765"}],"container-title":["Human &amp; Experimental Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0960327120947793","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0960327120947793","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0960327120947793","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:49:58Z","timestamp":1777448998000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0960327120947793"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,13]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1177\/0960327120947793"],"URL":"https:\/\/doi.org\/10.1177\/0960327120947793","relation":{},"ISSN":["0960-3271","1477-0903"],"issn-type":[{"value":"0960-3271","type":"print"},{"value":"1477-0903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,13]]}}}