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Twenty-four male rats were divided into 4 groups: control (0.1% DMSO), NP group (50 mg\/kg), NP+NOB group (50 mg\/kg + 25 mg\/kg), and NOB group (25 mg\/kg). Our results revealed that NP brought down the activities of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione reductase (GSR), while elevated the level of thiobarbituric acid reactive substances (TBARS). Additionally, NP decreased the level of follicle-stimulating hormone (FSH), luteinizing hormone (LH), plasma testosterone, daily sperm production (DSP), epididymal sperm count, viability, motility, gene expression of testicular steroidogenic enzymes (StAR, 3\u03b2-HSD and 17\u03b2-HSD) and anti-apoptotic protein (Bcl-2), as well as number of spermatogenic cells belonging to various stages. Whereas, sperm (head, mid-piece\/neck and tail) abnormalities, expression of apoptotic proteins (Bax and caspase-3), and histopathological damages were increased. However, NOB remarkably reversed all the damages caused by NP. Therefore, it is deduced that NOB could be used as a potential therapeutic to counter the NP-prompted oxidative stress and apoptotic damages in testes.<\/jats:p>","DOI":"10.1177\/0960327120950007","type":"journal-article","created":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T10:43:07Z","timestamp":1597920187000},"page":"403-416","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":45,"title":["Nobiletin ameliorates nonylphenol-induced testicular damage by improving biochemical, steroidogenic, hormonal, spermatogenic, apoptotic and histological profile"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8398-5364","authenticated-orcid":false,"given":"Muhammad Umar","family":"Ijaz","sequence":"first","affiliation":[{"name":"Department of Zoology, Wildlife and Fisheries, University of Agriculture, Faisalabad, 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