{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:22:53Z","timestamp":1792801373130,"version":"4.5.0"},"reference-count":66,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T00:00:00Z","timestamp":1597795200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>\n                      The present study aimed to examine the effect of paricalcitol (PRC) and vitamin D\n                      <jats:sub>3<\/jats:sub>\n                      (vit D\n                      <jats:sub>3<\/jats:sub>\n                      ) on doxorubicin (DOX)-induced nephrotoxicity in rats.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      Forty-two Wistar rats were randomly categorized into six groups: control; 2) PRC(0.5 \u00b5g\/kg) and 3) vit D\n                      <jats:sub>3<\/jats:sub>\n                      (5.000 IU\/kg) administered for 14 days; 4) DOX, 18 mg\/kg administered on the 12th, 13th and 14th days of the study; 5) PRC (0.5 \u00b5g\/kg, +DOX(18 mg\/kg); vit D\n                      <jats:sub>3(<\/jats:sub>\n                      5.000 IU)+DOX(18 mg\/kg). On the 15th day of the experiment,\n                      <jats:sup>99m<\/jats:sup>\n                      Tc-DMSA uptake level and biochemical parameter in serum and tissue were assay.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Activities of\n                      <jats:sup>99m<\/jats:sup>\n                      Technetium-Dimercaptosuccinic Acid (\n                      <jats:sup>99m<\/jats:sup>\n                      Tc-DMSA) were lower in groups receiving DOX and\/or PRC+DOX, vit D\n                      <jats:sub>3<\/jats:sub>\n                      +DOX than in control groups. The\n                      <jats:sup>99m<\/jats:sup>\n                      Tc-DMSA level in the group PRC+DOX and vit D\n                      <jats:sub>3<\/jats:sub>\n                      +DOX were importantly higher than DOX group. DOX caused an important increase in blood urea nitrogen (BUN), creatinine, Tumor Necrosis Factor-\u03b1(TNF- \u03b1), interleukin-6(IL-6) and nitric oxide(NO) levels compared to control groups. However, PRC and vit D\n                      <jats:sub>3<\/jats:sub>\n                      pretreatments lowered them. Uptake of\n                      <jats:sup>99m<\/jats:sup>\n                      Tc-DMSA level was higher in groups PRC+DOX than in vit D\n                      <jats:sub>3<\/jats:sub>\n                      +DOX group. Administration of PRC and vit D\n                      <jats:sub>3<\/jats:sub>\n                      alone did not change alterations all of parameters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      The results indicated that PRC administration protects kidney in DOX-induced nephrotoxic rats. In addition, PRC has a stronger nephroprotective effect than vit D\n                      <jats:sub>3<\/jats:sub>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0960327120950010","type":"journal-article","created":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T05:42:45Z","timestamp":1597815765000},"page":"274-283","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Evaluation of the protective effect of paricalcitol and vitamin D\n                    <sub>3<\/sub>\n                    at doxorubicin nephrotoxicity in rats with\n                    <sup>99m<\/sup>\n                    Technetium-dimercaptosuccinic acid renal scintigraphy and biochemical methods"],"prefix":"10.1177","volume":"40","author":[{"given":"Fadime","family":"Demir","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Tokat Gaziosmanpasa University, 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