{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:47:40Z","timestamp":1777668460718,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T00:00:00Z","timestamp":1599696000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100009573","name":"Universidad Nacional de Rosario","doi-asserted-by":"publisher","award":["PIP 2016-2019, grant number BIO 479"],"award-info":[{"award-number":["PIP 2016-2019, grant number BIO 479"]}],"id":[{"id":"10.13039\/100009573","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Agencia Nacional de Promoci\u00f3n Cient\u013afica y Tecnol\u00f3gica","award":["PICT 2017: grant number 0936"],"award-info":[{"award-number":["PICT 2017: grant number 0936"]}]},{"DOI":"10.13039\/501100002923","name":"consejo nacional de investigaciones cient\u013aficas y t\u00e9cnicas","doi-asserted-by":"publisher","award":["PIP 2015-2017: grant number 0460"],"award-info":[{"award-number":["PIP 2015-2017: grant number 0460"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:p>\n                    Mercury is a widespread pollutant. Mercuric ions uptake into tubular cells is supported by the Organic anion transporter 1 (Oat1) and 3 (Oat3) and its elimination into urine is through the Multidrug resistance-associated protein 2 (Mrp2). We investigated the effect of recombinant human erythropoietin (Epo) on renal function and on renal expression of Oat1, Oat3, and Mrp2 in a model of mercuric chloride (HgCl\n                    <jats:sub>2<\/jats:sub>\n                    )-induced renal damage. Four experimental groups of adult male Wistar rats were used: Control, Epo, HgCl\n                    <jats:sub>2<\/jats:sub>\n                    , and Epo + HgCl\n                    <jats:sub>2<\/jats:sub>\n                    . Epo (3000 IU\/kg, b.w., i.p.) was administered 24 h before HgCl\n                    <jats:sub>2<\/jats:sub>\n                    (4 mg\/kg, b.w., i.p.). Experiments were performed 18 h after the HgCl\n                    <jats:sub>2<\/jats:sub>\n                    dose. Parameters of renal function and structure were evaluated. The protein expression of Oat1, Oat3 and Mrp2 in renal tissue was assessed by immunoblotting techniques. Mercury levels were determined by cold vapor atomic absorption spectrometry. Pretreatment with Epo ameliorated the HgCl\n                    <jats:sub>2<\/jats:sub>\n                    -induced tubular injury as assessed by histopathology and urinary biomarkers. Immunoblotting showed that pretreatment with Epo regulated the renal expression of mercury transporters in a way to decrease mercury content in the kidney. Epo pretreatment ameliorates HgCl\n                    <jats:sub>2<\/jats:sub>\n                    -induced renal tubular injury by modulation of mercury transporters expression in the kidneys.\n                  <\/jats:p>","DOI":"10.1177\/0960327120958109","type":"journal-article","created":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T09:32:33Z","timestamp":1599730353000},"page":"515-525","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Effect of erythropoietin on mercury-induced nephrotoxicity: Role of membrane transporters"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0136-3634","authenticated-orcid":false,"given":"MH","family":"Hazelhoff","sequence":"first","affiliation":[{"name":"\u00c1rea Farmacolog\u00eda, Facultad de Ciencias Bioqu\u00edmicas y Farmac\u00e9uticas, Universidad Nacional de Rosario, CONICET, Rosario, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8133-0137","authenticated-orcid":false,"given":"AM","family":"Torres","sequence":"additional","affiliation":[{"name":"\u00c1rea Farmacolog\u00eda, Facultad de Ciencias Bioqu\u00edmicas y Farmac\u00e9uticas, Universidad Nacional de Rosario, CONICET, Rosario, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,9,10]]},"reference":[{"key":"bibr1-0960327120958109","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-59453-2.00046-9"},{"key":"bibr2-0960327120958109","doi-asserted-by":"publisher","DOI":"10.1007\/s10661-019-7528-7"},{"key":"bibr3-0960327120958109","first-page":"113","volume":"52","author":"Zalups R","year":"2000","journal-title":"Pharmacol 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