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The prevalence of this disease among reproductive-age women is almost 10\u201315%. High levels of IL-6 and IL-8 have been found in the peritoneal fluid (PF) of women with endometriosis and are involved in its pathogenesis. Isolated stromal cells from 12 ectopic and eutopic endometrial biopsies of women with ovarian endometrioma and also 12 endometrial biopsies of nonendometriotic controls were treated with 1.1 \u00b5M pyrvinium pamoate, a Wnt\/\u03b2-catenin signaling pathway inhibitor, for 72 hrs. Before treatment, mRNA gene expression and secretion of IL-6 and IL-8 were significantly higher in ectopic (EESCs) than eutopic (EuESCs) and control (CESCs) endometrial stromal cells. After treatment, mRNA gene expression and also secretion of IL-6 and IL-8 were significantly reduced. Our Findings showed that pyrvinium pamoate suppresses the mRNA gene expression and secretion of IL-6 and IL-8 in human endometriotic stromal cells. Additional investigations on this compound are required before clinical application.<\/jats:p>","DOI":"10.1177\/0960327120964543","type":"journal-article","created":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T06:56:47Z","timestamp":1601967407000},"page":"649-660","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Pyrvinium pamoate induces in-vitro suppression of IL-6 and IL-8 produced by human endometriotic stromal cells"],"prefix":"10.1177","volume":"40","author":[{"given":"Amin","family":"Karamian","sequence":"first","affiliation":[{"name":"Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahrokh","family":"Paktinat","sequence":"additional","affiliation":[{"name":"Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti 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