{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:48:04Z","timestamp":1777668484895,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T00:00:00Z","timestamp":1603411200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec>\n                    <jats:title>Aim of the work:<\/jats:title>\n                    <jats:p>This prospective study was conducted to evaluate the clinical reliability of N-terminal fragment of proB-type natriuretic peptide (NT-proBNP) in identifying patients with cardiotoxicity in the early hours following scorpion sting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and methods:<\/jats:title>\n                    <jats:p>This study involved 483 children aging between 2\u201317 years who were admitted to Minia University Poisoning Control Center from 1st January 2010 to 31st December 2019 with a history of scorpion sting, and on clinical evaluation symptoms were manifested. All subjects were clinically examined, investigated for NT-proBNP and CPK-MB on admission, 6 h and 24 h post-envenomation; and subjected to 24 h cardiac monitoring with periodic ECG every 6 h.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Assessment of CPK-MB levels showed a significant increase in all moderate to severe cases 6 h post-envenomation. Assessment of NT-proBNP levels showed a significant increase in all moderate to severe cases on admission and 6 h post-envenomation. Moreover, there was a significant decrease in the NT-proBNP level after 24 h compared with that measured on admission. The sensitivity of NT-proBNP for the diagnosis of myocardial injury at hospital admission was significantly higher than that of CPK-MB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>NT-proBNP may be a valuable and sensitive laboratory biomarker to predict cardiotoxicity of scorpion sting in the early hours.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0960327120968863","type":"journal-article","created":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T06:11:50Z","timestamp":1603433510000},"page":"754-760","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Scorpion sting: N-terminal fragment of proB-type natriuretic peptide as an early predictor of pediatric cardiotoxicity"],"prefix":"10.1177","volume":"40","author":[{"given":"Mohamed AM","family":"Khalaf","sequence":"first","affiliation":[{"name":"Department of Forensic Medicine & Clinical Toxicology, Faculty of Medicine, Minia University, Minia, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed A Bahaa","family":"El-deen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Minia University, Minia, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7113-7157","authenticated-orcid":false,"given":"Asmaa Mohammed","family":"Hishmat","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine & Clinical Toxicology, Faculty of Medicine, Minia University, Minia, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,10,23]]},"reference":[{"key":"bibr1-0960327120968863","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2019.01.004"},{"key":"bibr2-0960327120968863","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012473270-4\/50099-7"},{"key":"bibr3-0960327120968863","first-page":"67","volume":"2","author":"Khalaf MA","year":"2012","journal-title":"Egy J Foren Sci"},{"key":"bibr4-0960327120968863","doi-asserted-by":"publisher","DOI":"10.1016\/0041-0101(95)00005-7"},{"key":"bibr5-0960327120968863","first-page":"363","volume":"22","author":"Clairfeuille T","year":"2019","journal-title":"Science"},{"issue":"4","key":"bibr6-0960327120968863","first-page":"368","volume":"117","author":"Rostagno G","year":"2019","journal-title":"Arch Argent Pediatr"},{"key":"bibr7-0960327120968863","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.90.1.195"},{"issue":"5","key":"bibr8-0960327120968863","first-page":"265","volume":"47","author":"Hammerer-Lercher A","year":"2001","journal-title":"Clin Lab"},{"key":"bibr9-0960327120968863","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13976-1"},{"key":"bibr10-0960327120968863","first-page":"2678","volume":"273","author":"Bruneau BG","year":"1997","journal-title":"Am J Physiol"},{"key":"bibr11-0960327120968863","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)12083-4"},{"issue":"7","key":"bibr12-0960327120968863","doi-asserted-by":"crossref","first-page":"168","DOI":"10.4103\/0019-5359.125878","volume":"67","author":"Barakat AA","year":"2013","journal-title":"Ind J Med Sci"},{"key":"bibr13-0960327120968863","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-017-4061-0"},{"key":"bibr14-0960327120968863","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.2.169"},{"key":"bibr15-0960327120968863","doi-asserted-by":"publisher","DOI":"10.1177\/0960327109350667"},{"key":"bibr16-0960327120968863","doi-asserted-by":"publisher","DOI":"10.21608\/absb.2017.8163"},{"issue":"2","key":"bibr17-0960327120968863","first-page":"42","volume":"10","author":"Kashef S","year":"2002","journal-title":"Yazd Shahid Saddoghi Med J"},{"issue":"1","key":"bibr18-0960327120968863","first-page":"67","volume":"28","author":"Sakha K","year":"2006","journal-title":"Tabriz Uni Med J"},{"key":"bibr19-0960327120968863","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(05)70368-0"},{"key":"bibr20-0960327120968863","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2006.02.004"},{"key":"bibr21-0960327120968863","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2008.09.004"},{"issue":"5","key":"bibr22-0960327120968863","first-page":"439","volume":"67","author":"Goyffon M","year":"2007","journal-title":"Med Trop"},{"key":"bibr23-0960327120968863","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2018.08.008"},{"key":"bibr24-0960327120968863","doi-asserted-by":"publisher","DOI":"10.1080\/02724936.1991.11747506"},{"issue":"1","key":"bibr25-0960327120968863","first-page":"118","volume":"7","author":"Sagarad SV","year":"2013","journal-title":"J Clin Diagn Res"},{"key":"bibr26-0960327120968863","doi-asserted-by":"publisher","DOI":"10.1016\/j.wem.2018.06.013"},{"key":"bibr27-0960327120968863","volume-title":"Clinical methods: the history, physical, and laboratory examinations","author":"Cabaniss D","year":"1990","edition":"3"},{"key":"bibr28-0960327120968863","doi-asserted-by":"publisher","DOI":"10.1007\/s12012-010-9102-y"}],"container-title":["Human &amp; Experimental Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0960327120968863","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0960327120968863","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0960327120968863","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:50:09Z","timestamp":1777449009000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0960327120968863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,23]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1177\/0960327120968863"],"URL":"https:\/\/doi.org\/10.1177\/0960327120968863","relation":{},"ISSN":["0960-3271","1477-0903"],"issn-type":[{"value":"0960-3271","type":"print"},{"value":"1477-0903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,23]]}}}