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Alpha-lipoic acid (ALA) is a natural antioxidant offers protection against the developmental toxicity induced by drug- or toxicant-exposure or pathological conditions. This study was aimed at evaluating the protective effect of ALA against Ara-C induced developmental toxicity in rat fetus. Pregnant rats divided into five groups and received normal saline, ALA200 mg\/kg, Ara-C12.5 mg\/kg, Ara-C25 mg\/kg and, Ara-C25 mg\/kg plus ALA200 mg\/kg respectively from gestational day (GD) 8 to GD14 and sacrificed on GD21. Ara-C treatment led to a significant and dose-dependent decrease in food intake, weight gain, placental weight, and an increase in oxidative stress in pregnant rats. Further, the in-utero exposure to Ara-C led to an increase in fetal mortality, resorptions, oxidative stress, external morphological anomalies and limb abnormalities, and impaired ossification. Co-administration of ALA resulted in amelioration of the footprints of Ara-C induced toxicity in pregnant rats as well as the fetus. These findings indicate that the ALA supplementation offers protection against developmental toxicity caused by Ara-C prenatal exposure in rats.<\/jats:p>\n                  <jats:p\/>","DOI":"10.1177\/0960327120975114","type":"journal-article","created":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T06:06:26Z","timestamp":1606111586000},"page":"851-868","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Alpha-lipoic acid ameliorates cytarabine-induced developmental anomalies in rat fetus"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1414-3278","authenticated-orcid":false,"given":"Ramanachary","family":"Namoju","sequence":"first","affiliation":[{"name":"Department of Pharmacology, GITAM Institute of Pharmacy, GITAM Deemed to be University, Vishakhapatnam, Andhra Pradesh, India"},{"name":"Department of Pharmacology, Bhaskar Pharmacy College, Jawaharlal Nehru Technical University, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naga Kavitha","family":"Chilaka","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, GITAM Institute of Pharmacy, GITAM Deemed to be University, Vishakhapatnam, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,11,23]]},"reference":[{"key":"bibr1-0960327120975114","unstructured":"WHO-Cancer Facts [Internet]. 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