{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:35:38Z","timestamp":1785436538244,"version":"3.56.0"},"reference-count":35,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T00:00:00Z","timestamp":1609286400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Institution foundation of the first affiliated hospital of Xi\u2019an Jiaotong University","award":["2019ZYTS-10"],"award-info":[{"award-number":["2019ZYTS-10"]}]},{"DOI":"10.13039\/501100007128","name":"natural science foundation of shaanxi province","doi-asserted-by":"crossref","award":["2018JM7021"],"award-info":[{"award-number":["2018JM7021"]}],"id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:p>JZL184 is a selective inhibitor of monoacylglycerol lipase (MAGL) that has neuroprotective effect. However, the role of JZL184 in cerebral ischemia\/reperfusion (I\/R) injury and the exact mechanism have not been fully understood. This study was designed to elucidate the role of JZL184 in cerebral I\/R injury induced by oxygen-glucose deprivation\/reoxygenation (OGD\/R) in hippocampal neurons. Hippocampal neurons were pretreated with various concentrations of JZL184 for 2 h, followed by OGD for 3 h and reoxygen for 24 h. Our results showed that JZL184 improved cell viability in hippocampal neurons in response to OGD\/R. JZL184 treatment significantly inhibited the production of reactive oxygen species (ROS) and malondialdehyde (MDA), as well as increased superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities in OGD\/R-induced hippocampal neurons. The increased TNF-\u03b1, IL-1\u03b2, and IL-6 productions in OGD\/R-induced hippocampal neurons were decreased after treatment with JZL184. Moreover, the OGD\/R-caused intense TUNEL staining in hippocampal neurons was attenuated by JZL184. JZL184 treatment prevented OGD\/R-caused increases in bax and cleaved caspase-3 expression and a decrease in bcl-2 expression. Furthermore, JZL184 treatment significantly promoted the activation of Nrf2\/ARE signaling pathway in OGD\/R-induced hippocampal neurons. Additionally, silencing of Nrf2 reversed the protective effect of JZL184 on hippocampal neurons under OGD\/R condition. Taken together, these findings suggested that JZL184 exerted protective effect against OGD\/R-induced injury in hippocampal neurons via activating Nrf2\/ARE signaling pathway, which provided in vitro experimental support for the therapeutic benefit of JZL184 in cerebral ischemia.<\/jats:p>","DOI":"10.1177\/0960327120984220","type":"journal-article","created":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T04:48:31Z","timestamp":1609303711000},"page":"1084-1094","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["JZL184 protects hippocampal neurons from oxygen-glucose deprivation-induced injury via activating Nrf2\/ARE signaling pathway"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8779-5720","authenticated-orcid":false,"given":"Jing","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Emergency, The First Affiliated Hospital of Xi\u2019an Jiaotong University, Shaanxi Province, People\u2019s Republic of China"},{"name":"These authors contributed equally to this work."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinyue","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, The First Affiliated Hospital of Xi\u2019an Jiaotong University, Shaanxi Province, People\u2019s Republic of China"},{"name":"These authors contributed equally to this work."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Huo","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Xi\u2019an Jiaotong University, Shaanxi Province, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinxue","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Emergency, The First Affiliated Hospital of Xi\u2019an Jiaotong University, Shaanxi Province, 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