{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T04:24:35Z","timestamp":1781065475666,"version":"3.54.1"},"reference-count":61,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T00:00:00Z","timestamp":1618185600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>A high cholesterol diet (HCD) is known to cause metabolic dysregulation, oxidative stress, cardiovascular diseases and atherogenesis. Zingerone is a pharmacologically active component of dry ginger. Zingerone has been shown to have a wide range of pharmacological properties, including scavenging free radicals, high antioxidant activity, suppressing lipid peroxidation and anti-inflammatory. This study aimed to investigate the effects of Zingerone on HCD-induced atherosclerosis in rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Animals were divided into four categories (n = 6). Group I: normal control, Group II: zingerone control (20 mg\/kg b.wt.), group III: HCD-induced atherosclerosis, Group IV: HCD + zingerone, respectively, for 8 weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The HCD-fed rats resulted in a significant increase in an atherosclerotic lesion, lipid peroxidation, lipid profile, high-density lipoprotein concentration, cardiac markers, body weight, reduced antioxidant status, and displayed atherosclerosis. These findings were conventional by up-regulated expression of lipid regulatory genes like sterol-regulatory-element-binding protein-c (SREBP-c), fatty acid synthase (FAS), acetyl-CoA carboxylase (ACC), acetyl-CoA synthetase (ACS), liver X receptor\u2013alpha (LXR-\u03b1), and down-regulated expression of acetyl-CoA oxidase (ACO), peroxisome proliferator-activated receptor-alpha (PPAR-\u03b1) and carnitine palmitoyl transferase-1 (CPT-1) in HCD-fed rats. These significant changes were observed in the zingerone-treated rats for the last 4 weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>These findings suggest that zingerone reduced atherosclerosis by modulated the atherosclerotic lesion, lipid profile, antioxidant status and lipid regulatory gene expression in HCD-fed rats.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09603271211006170","type":"journal-article","created":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T02:52:06Z","timestamp":1618282326000},"page":"1732-1745","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Protective effects of zingerone on high cholesterol diet-induced atherosclerosis through lipid regulatory signaling pathway"],"prefix":"10.1177","volume":"40","author":[{"given":"X","family":"Geng","sequence":"first","affiliation":[{"name":"Department of Emergency, Tangshan Gongren Hospital, Tangshan, Hebei, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Liu","sequence":"additional","affiliation":[{"name":"Medical Imaging Department, Tangshan Gongren Hospital, Tangshan, Hebei, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q","family":"Yuwen","sequence":"additional","affiliation":[{"name":"Medical Imaging Department, Yanda Hospital, Langfang, Hebei, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Tangshan Gongren Hospital, Tangshan, Hebei, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Emergency, Luanzhou People\u2019s Hospital, Tangshan, Hebei, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Zunhua People\u2019s Hospital, Tangshan, Hebei, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3718-4080","authenticated-orcid":false,"given":"J","family":"Sun","sequence":"additional","affiliation":[{"name":"Medical Imaging Department, Tangshan Gongren Hospital, Tangshan, Hebei, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,4,12]]},"reference":[{"key":"bibr1-09603271211006170","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000020190.45892.75"},{"key":"bibr2-09603271211006170","doi-asserted-by":"publisher","DOI":"10.1161\/hc0902.104353"},{"key":"bibr3-09603271211006170","doi-asserted-by":"publisher","DOI":"10.1038\/nature05487"},{"key":"bibr4-09603271211006170","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.2001.280.4.C719"},{"key":"bibr5-09603271211006170","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.02.038"},{"key":"bibr6-09603271211006170","doi-asserted-by":"publisher","DOI":"10.2147\/vhrm.2008.04.01.235"},{"key":"bibr7-09603271211006170","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfda.2016.01.012"},{"key":"bibr8-09603271211006170","unstructured":"Takizawa M, Sato M, Kusuoku H, et al.; Kao Corp, assignee. 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