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We investigate luteolin protective effects on hepatorenal toxicity associated with doxorubicin treatment in rats. For 2 weeks, randomly assigned rat cohorts were treated as follows: control, luteolin (100 mg\/kg; per os), doxorubicin alone (2mg\/kg; by intraperitoneal injection), co-treated cohorts received luteolin (50 and 100 mg\/kg) in addition to doxorubicin. Treatment with doxorubicin alone significantly (p &lt; 0.05) increased biomarkers of hepatorenal toxicities in the serum. Doxorubicin also reduced relative organ weights, antioxidant capacity, and anti-inflammatory cytokine interleukine-10. Doxorubicin also increased reactive oxygen and nitrogen species, lipid peroxidation, pro-inflammatory-interleukin-1\u03b2 and tumour necrosis factor-\u03b1-cytokine, and apoptotic caspases-3 and -9). Morphological damage accompanied these biochemical alterations in the rat\u2019s liver and kidney treated with doxorubicin alone. Luteolin co-treatment dose-dependently abated doxorubicin-mediated toxic responses, improved antioxidant capacity and interleukine-10 level. Luteolin reduced (p &lt; 0.05) lipid peroxidation, caspases-3 and -9 activities and marginally improved rats\u2019 survivability. Similarly, luteolin co-treated rats exhibited improvement in hepatorenal pathological lesions observed in rats treated with doxorubicin alone. In summary, luteolin co-treatment blocked doxorubicin-mediated hepatorenal injuries linked with pro-oxidative, inflammatory, and apoptotic mechanisms. Therefore, luteolin can act as a chemoprotective agent in abating toxicities associated with doxorubicin usage and improve its therapeutic efficacy.<\/jats:p>","DOI":"10.1177\/09603271211006171","type":"journal-article","created":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T03:32:43Z","timestamp":1617852763000},"page":"1656-1672","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":86,"title":["Luteolin attenuates doxorubicin-induced derangements of liver and kidney by reducing oxidative and inflammatory stress to suppress apoptosis"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4973-0376","authenticated-orcid":false,"given":"SE","family":"Owumi","sequence":"first","affiliation":[{"name":"Cancer Research and Molecular Biology Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DO","family":"Lewu","sequence":"additional","affiliation":[{"name":"Cancer Research and Molecular Biology Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"UO","family":"Arunsi","sequence":"additional","affiliation":[{"name":"School of Medicine, Cancer Immunology and Biotechnology, Department of Biosciences, University of Nottingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AK","family":"Oyelere","sequence":"additional","affiliation":[{"name":"School of Chemistry and Biochemistry, Parker H. 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