{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T07:00:12Z","timestamp":1778742012555,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"12_suppl","license":[{"start":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T00:00:00Z","timestamp":1630368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Shenfu injection (SFI) has been reported to have a protection against myocardial ischemia-reperfusion (MI\/R) injury. However, the changes of adenosine receptors in MI\/R postconditioning when pretreated with SFI are unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Forty-five rats were randomly divided into sham group (sham), MI\/R postconditioning group (MI\/R-post), low-dose SFI group (1\u00a0mL\/kg), middle-dose SFI group (2.5\u00a0mL\/kg), and high-dose SFI group (5\u00a0mL\/kg). In SFI groups, SFI was intravenously injected before reperfusion, and rats were treated with ischemic postconditioning after ischemia for 30\u00a0min. After 24\u00a0h of reperfusion, the levels of Ca\n                      <jats:sup>2+<\/jats:sup>\n                      and cAMP in blood platelets were analyzed. Myocardial infarct volume and myocardial pathology were observed. The levels of adenosine receptor subtypes A\n                      <jats:sub>1<\/jats:sub>\n                      , A\n                      <jats:sub>2b<\/jats:sub>\n                      , and A\n                      <jats:sub>3<\/jats:sub>\n                      in myocardium were analyzed using immunohistochemistry and Western blot. The oxidative stress\u2013related indicators were also observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with the MI\/R-post group, SFI ameliorated the MI\/R injury by decreasing the myocardial infarct area, oxidative stress, and concentration of Ca\n                      <jats:sup>2+<\/jats:sup>\n                      and cAMP ( p &lt; 0.01). Pretreatment with SFI enhanced the expression of adenosine receptors A\n                      <jats:sub>1<\/jats:sub>\n                      and A\n                      <jats:sub>2b<\/jats:sub>\n                      in a dose manner compared with the MI\/R-post group. In contrast, the levels of adenosine receptor A\n                      <jats:sub>3<\/jats:sub>\n                      were increased after MI\/R postconditioning compared with the sham group, and its expression continued to increase with the increase of SFI. Furthermore, the oxidative stress reduced with the concentrations of SFI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These results demonstrated that pretreatment with SFI might regulate the expression of adenosine receptors to improve the MI\/R postconditioning.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09603271211041668","type":"journal-article","created":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T22:47:52Z","timestamp":1630450072000},"page":"S300-S309","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Effects of Shenfu injection on myocardial adenosine receptors in rats with myocardial ischemia-reperfusion postconditioning"],"prefix":"10.1177","volume":"40","author":[{"given":"Jie","family":"Wang","sequence":"first","affiliation":[{"name":"Cardiac Intensive Care Unit, Yantaishan Hospital, Yantai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Gansu Provincial Hospital, Lanzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiping","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Yantaishan Hospital, Yantai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanying","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Public Health, LKS Faculty of Medicine, The University of Hongkang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanfang","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Yantaishan Hospital, Yantai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenbo","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Yantaishan Hospital, Yantai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7226-9450","authenticated-orcid":false,"given":"Fangming","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Yantaishan Hospital, Yantai, 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