{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T18:17:46Z","timestamp":1788891466438,"version":"build-2803163510"},"reference-count":69,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Researchers Supporting Project","award":["RSP-2021\/124"],"award-info":[{"award-number":["RSP-2021\/124"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Purpose:\u00a0The current investigation was carried out to evaluate the efficacy of myricetin in ethanol-induced liver toxicity in Wistar rats.\u00a0<\/jats:p>\n                  <jats:p>Research Design:\u00a0Twenty-four rats were randomly divided into four groups with six animals per group. Group-I animals were administered with vehicle (distilled water), Group II, III, and IV were treated orally with sequential (per week) increase in the dose of ethanol (5, 8, 10, and 12 g\/kg b wt per week in each group) for 28 days. Myricetin was treated orally to Group-III and IV animals at the respective doses of 25 mg\/kg b wt. and 50 mg\/kg b wt.\u00a0<\/jats:p>\n                  <jats:p>Results:\u00a0Our results showed that myricetin prevented hepatotoxicity by modulating the production of free radicals, ethanol metabolizing enzymes, and inflammatory markers in vivo. Myricetin also helped maintain lipid membrane integrity, oxidant-antioxidant status, and histoarchitecture. Ethanol administration caused elevation in XO, ADH, and CYP2E1 in hepatic tissue, which significantly normalized with myricetin administration. After ethanol administration, there was a steep increase in the hepatotoxicity biomarkers, including ALT, MDA, and AST. The level of cytotoxicity marker LDH also increased after ethanol administration; myricetin administration decreased the level of all these markers. Moreover, myricetin treatment also reduced ethanol-induced inflammatory markers such as NF-\u03baB and IL-6.\u00a0<\/jats:p>\n                  <jats:p>Conclusion:\u00a0Findings from the current study demonstrate that myricetin administration prevents alcohol-induced hepatic injury by influencing the metabolism of ethanol, inhibiting oxidative stress, maintaining lipid profile, and suppressing inflammatory markers.<\/jats:p>","DOI":"10.1177\/09603271211066843","type":"journal-article","created":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T10:06:46Z","timestamp":1644833206000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Myricetin (3,3\n                    <sup>\u2032<\/sup>\n                    ,4\n                    <sup>\u2032<\/sup>\n                    ,5,5\n                    <sup>\u2032<\/sup>\n                    ,7-hexahydroxyflavone) prevents ethanol-induced biochemical and inflammatory damage in the liver of Wistar rats"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6360-8457","authenticated-orcid":false,"given":"Sheikh Bilal","family":"Ahmad","sequence":"first","affiliation":[{"name":"Division of Veterinary Biochemistry, Faculty of Veterinary Science and Animal Husbandry, SKUAST-Kashmir, Srinagar, J&K, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahzada Mudaisr","family":"Rashid","sequence":"additional","affiliation":[{"name":"Division of Veterinary Biochemistry, Faculty of Veterinary Science and Animal Husbandry, SKUAST-Kashmir, Srinagar, J&K, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adil Farooq","family":"Wali","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, RAK College of Pharmaceutical Sciences, RAK Medical and Health Sciences University, Ras Al Khaimah, UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shafat","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Government Medical College, (GMC-Srinagar), KaranNagar Srinagar, J&K, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9995-6576","authenticated-orcid":false,"given":"Muneeb U","family":"Rehman","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mir Tahir","family":"Maqbool","sequence":"additional","affiliation":[{"name":"National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Nadeem","sequence":"additional","affiliation":[{"name":"Department of Pharmacology & Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheikh Fayaz","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Pharmacology & Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahid","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Amity Institute of Biotechnology, Amity University, Noida, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,2,14]]},"reference":[{"key":"bibr1-09603271211066843","doi-asserted-by":"publisher","DOI":"10.4103\/0976-433X.114973"},{"key":"bibr2-09603271211066843","volume-title":"Global status report on alcohol and 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