{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:10:40Z","timestamp":1792455040954,"version":"4.5.0"},"reference-count":44,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Scorpion envenomation is a serious public health issue.\u00a0 Androctonus mauretanicus\u00a0( Am) and\u00a0 Buthus occitanus\u00a0( Bo) are the most dangerous scorpions in Morocco. Despite their medical relevance, no study has yet related their kinetics of symptom apparition and the consequent tissue disorders at the same interval post-injection. This work achieved the first comparative pathophysiological and toxic-symptoms study between the\u00a0 Am\u00a0and\u00a0 Bo\u00a0venoms from a biochemical, toxicological and physiopathological standpoint. The activity of venoms and their subletal dose were determined by administration of increasing concentrations of the venoms. 30, 60 and 120 min following the experimental envenomation in mice, the profile of clinical symptoms was underlined and the main organs: brain, heart, lungs, liver and kidneys were removed for histological examination. The\u00a0 Am\u00a0venom is a rich source of proteins and three-times more toxic than the\u00a0 Bo. The most observed clinical symptoms are neurological and cardiopulmonary. The\u00a0 Am\u00a0venom caused histopathological alterations at 30, 60, and 120\u00a0min which were more important than the\u00a0 Bo. This study highlighted that both venoms exhibited a strong toxicity with variable intensities. Moreover, we showed the presence of correlation between the level of histopathological disorders observed and the intensity of signs appeared at the same time following venom inoculation.<\/jats:p>","DOI":"10.1177\/09603271211072872","type":"journal-article","created":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T02:41:11Z","timestamp":1644288071000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Induced pathophysiological alterations by the venoms of the most dangerous Moroccan scorpions\n                    <i>Androctonus mauretanicus<\/i>\n                    and\n                    <i>Buthus occitanus<\/i>\n                    : A comparative pathophysiological and toxic-symptoms study"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5547-2684","authenticated-orcid":false,"given":"Bouchra","family":"Darkaoui","sequence":"first","affiliation":[{"name":"Laboratory of Venoms and Toxins, Pasteur Institute of Morocco, Casablanca, Morocco"},{"name":"Laboratory of Molecular Genetics, Physiopathology and Biotechnology, Faculty of Sciences Ain Chock, Hassan II University of Casablanca, Casablanca, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayoub","family":"Lafnoune","sequence":"additional","affiliation":[{"name":"Laboratory of Venoms and Toxins, Pasteur Institute of Morocco, Casablanca, Morocco"},{"name":"Laboratory of Molecular Genetics, Physiopathology and Biotechnology, Faculty of Sciences Ain Chock, Hassan II University of Casablanca, Casablanca, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima","family":"Chgoury","sequence":"additional","affiliation":[{"name":"Laboratory of Venoms and Toxins, Pasteur Institute of Morocco, Casablanca, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khadija","family":"Daoudi","sequence":"additional","affiliation":[{"name":"Laboratory of Venoms and Toxins, Pasteur Institute of Morocco, Casablanca, Morocco"},{"name":"Laboratory of Molecular Genetics, Physiopathology and Biotechnology, Faculty of Sciences Ain Chock, Hassan II University of Casablanca, Casablanca, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salma","family":"Chakir","sequence":"additional","affiliation":[{"name":"Laboratory of Venoms and Toxins, Pasteur Institute of Morocco, Casablanca, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khadija","family":"Mounaji","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Genetics, Physiopathology and Biotechnology, Faculty of Sciences Ain Chock, Hassan II University of Casablanca, Casablanca, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Karkouri","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology, University Hospital of Ibn Rochd, Casablanca, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachida","family":"Cadi","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Genetics, Physiopathology and Biotechnology, Faculty of Sciences Ain Chock, Hassan II University of Casablanca, Casablanca, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7058-0763","authenticated-orcid":false,"given":"Oukkache","family":"Naoual","sequence":"additional","affiliation":[{"name":"Laboratory of Venoms and Toxins, Pasteur Institute of Morocco, Casablanca, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,2,7]]},"reference":[{"key":"bibr1-09603271211072872","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2008.05.021"},{"key":"bibr2-09603271211072872","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S24754"},{"issue":"12","key":"bibr3-09603271211072872","first-page":"1","volume":"42","author":"Ait Laaradia M","year":"2021","journal-title":"Uttar Pradesh J 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Etude des effets histopathologiques engendr\u00e9s par le venin du scorpion marocain \u00ab\n                      Androctonus mauretanicus mauretanicus\n                      \u00bb et par sa fraction toxique chez la souris. In: 3rd International SMBBM Congress, IUBMB Special Meeting & 6th FASBMB Congress, Marrakech, 20\u201324 April 2009, 2019."},{"key":"bibr39-09603271211072872","first-page":"1","volume":"4","author":"Chgoury F","year":"2015","journal-title":"Biochem Pharmacol (Los Angel)"},{"key":"bibr40-09603271211072872","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2018.03.001"},{"key":"bibr41-09603271211072872","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2017.10.003"},{"key":"bibr42-09603271211072872","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2009.08.014"},{"key":"bibr43-09603271211072872","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2011.12.011"},{"key":"bibr44-09603271211072872","doi-asserted-by":"publisher","DOI":"10.1080\/15569543.2018.1446028"}],"container-title":["Human &amp; Experimental Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09603271211072872","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09603271211072872","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09603271211072872","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:45:21Z","timestamp":1777448721000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09603271211072872"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":44,"alternative-id":["10.1177\/09603271211072872"],"URL":"https:\/\/doi.org\/10.1177\/09603271211072872","relation":{},"ISSN":["0960-3271","1477-0903"],"issn-type":[{"value":"0960-3271","type":"print"},{"value":"1477-0903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"article-number":"09603271211072872"}}