{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:32:27Z","timestamp":1777667547453,"version":"3.51.4"},"reference-count":45,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2021,2,16]],"date-time":"2021-02-16T00:00:00Z","timestamp":1613433600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:p>Tectorigenin (TEC) is an effective compound that derived from many plants, such as Iris unguicularis, Belamcanda chinensis and Pueraria thunbergiana Benth. Evidence suggested that TEC has anti-tumor, anti-oxidant activity, anti-bacterial and anti-inflammatory effects. In addition, there has some evidence indicated that TEC is a potential anti-stroke compound; however, its specific roles and associated mechanism have not yet been elucidated. In the present study, we aimed to investigate the anti-inflammatory, anti-oxidant activity and anti-apoptosis effects of TEC on oxygen-glucose deprivation\/reperfusion (OGD\/R)-induced HT-22 cells, and clarified the relevant mechanisms. Here, we observed that TEC significantly promoted cell survival, impeded cell apoptosis, inhibited ROS and inflammatory cytokines IL-1\u03b2, IL-6, TNF-\u03b1 production in OGD\/R-induced HT-22 cells. Moreover, TEC activated PI3K\/AKT signal pathway, increased PPAR\u03b3 expression and inhibited NF-\u03baB pathway activation in OGD\/R-induced HT-22 cells. Further studies indicated that PPAR\u03b3 inhibitor GW9662 activated NF-\u03baB pathway after TEC treatment in OGD\/R-induced HT-22 cells. Also, PI3K\/AKT inhibitor LY294002, PPAR\u03b3 inhibitor GW9662 and NF-\u03baB activator LPS both reversed the effects of TEC on OGD\/R-induced HT-22 cell biology. Taken together, this research confirmed that TEC benefit to HT-22 cell survival and against OGD\/R damage through the PI3K\/AKT and PPAR\u03b3\/NF-\u03baB pathways. These results indicated that TEC might be an effective compound in the treatment for ischemic brain injury.<\/jats:p>","DOI":"10.1177\/0960327121993213","type":"journal-article","created":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T19:29:21Z","timestamp":1613849361000},"page":"1320-1331","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Tectorigenin attenuates the OGD\/R-induced HT-22 cell damage through regulation of the PI3K\/AKT and the PPAR\u03b3\/NF-\u03baB pathways"],"prefix":"10.1177","volume":"40","author":[{"given":"Li","family":"Yao","sequence":"first","affiliation":[{"name":"Department of Neurology, The Hospital of Xidian Group, Xi\u2019an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meili","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juanli","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Hospital of Xidian Group, Xi\u2019an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Hospital of Xidian Group, Xi\u2019an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Hospital of Xidian Group, Xi\u2019an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojun","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Hospital of Xidian Group, Xi\u2019an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuo","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Emergency, The Hospital of Xidian Group, Xi\u2019an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Hospital of Xidian Group, Xi\u2019an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hang","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Hospital of Xidian Group, Xi\u2019an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiemin","family":"Zhai","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Hospital of Xidian Group, Xi\u2019an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianbo","family":"He","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Hospital of Xidian Group, Xi\u2019an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sha","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The Second Affiliated Hospital of Xi\u2019an Medical University, Xi\u2019an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9962-3213","authenticated-orcid":false,"given":"Zhengguo","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine, Xianyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,2,16]]},"reference":[{"key":"bibr1-0960327121993213","doi-asserted-by":"publisher","DOI":"10.1186\/s12984-019-0569-x"},{"key":"bibr2-0960327121993213","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30034-1"},{"key":"bibr3-0960327121993213","doi-asserted-by":"publisher","DOI":"10.1177\/2165079916665400"},{"key":"bibr4-0960327121993213","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2018.05.012"},{"key":"bibr5-0960327121993213","doi-asserted-by":"publisher","DOI":"10.1177\/1971400915576678"},{"key":"bibr6-0960327121993213","doi-asserted-by":"publisher","DOI":"10.1080\/09168451.2019.1654846"},{"key":"bibr7-0960327121993213","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6599"},{"key":"bibr8-0960327121993213","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840080132"},{"key":"bibr9-0960327121993213","doi-asserted-by":"publisher","DOI":"10.1021\/jf104018u"},{"key":"bibr10-0960327121993213","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.182707"},{"key":"bibr11-0960327121993213","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00462"},{"key":"bibr12-0960327121993213","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgi092"},{"key":"bibr13-0960327121993213","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2010.06.022"},{"issue":"11","key":"bibr14-0960327121993213","first-page":"841","volume":"12","author":"Ma CH","year":"2014","journal-title":"Chin J Nat Med"},{"key":"bibr15-0960327121993213","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-001-2129-7"},{"key":"bibr16-0960327121993213","doi-asserted-by":"publisher","DOI":"10.3109\/08923973.2013.799685"},{"key":"bibr17-0960327121993213","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2014.10.020"},{"key":"bibr18-0960327121993213","doi-asserted-by":"publisher","DOI":"10.1093\/femsle\/fnz112"},{"key":"bibr19-0960327121993213","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2013.10.022"},{"key":"bibr20-0960327121993213","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2005.06.043"},{"issue":"5","key":"bibr21-0960327121993213","first-page":"4431","volume":"14","author":"Gong P","year":"2017","journal-title":"Exp Ther Med"},{"key":"bibr22-0960327121993213","doi-asserted-by":"publisher","DOI":"10.1177\/0960327119851260"},{"key":"bibr23-0960327121993213","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2018.11.044"},{"key":"bibr24-0960327121993213","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2015.11.035"},{"key":"bibr25-0960327121993213","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-014-1272-8"},{"key":"bibr26-0960327121993213","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/2010675"},{"key":"bibr27-0960327121993213","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14214"},{"key":"bibr28-0960327121993213","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2018.02.014"},{"key":"bibr29-0960327121993213","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/4927430"},{"key":"bibr30-0960327121993213","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02408"},{"key":"bibr31-0960327121993213","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2019.03.015"},{"key":"bibr32-0960327121993213","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(13)70089-5"},{"key":"bibr33-0960327121993213","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2017.00467"},{"key":"bibr34-0960327121993213","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.93.331"},{"key":"bibr35-0960327121993213","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-6-54"},{"key":"bibr36-0960327121993213","doi-asserted-by":"publisher","DOI":"10.1080\/10286020902819822"},{"key":"bibr37-0960327121993213","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2017.02.009"},{"key":"bibr38-0960327121993213","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2006.05.022"},{"key":"bibr39-0960327121993213","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2019.04.031"},{"key":"bibr40-0960327121993213","doi-asserted-by":"publisher","DOI":"10.2174\/0929867322666150209154036"},{"key":"bibr41-0960327121993213","doi-asserted-by":"publisher","DOI":"10.2174\/156802609789869619"},{"key":"bibr42-0960327121993213","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.13271"},{"key":"bibr43-0960327121993213","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5388"},{"key":"bibr44-0960327121993213","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066417"},{"key":"bibr45-0960327121993213","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2014.993038"}],"container-title":["Human &amp; Experimental Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0960327121993213","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0960327121993213","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0960327121993213","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:47:06Z","timestamp":1777448826000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0960327121993213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,16]]},"references-count":45,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1177\/0960327121993213"],"URL":"https:\/\/doi.org\/10.1177\/0960327121993213","relation":{},"ISSN":["0960-3271","1477-0903"],"issn-type":[{"value":"0960-3271","type":"print"},{"value":"1477-0903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,16]]}}}