{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:18:08Z","timestamp":1791919088567,"version":"4.3.4"},"reference-count":43,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Testicular torsion is an emergency, mainly in newborn and adolescent males, resulting in testicular ischemia. The current study aimed to evaluate the effect of Idebenone (IDE) on testicular torsion\/detorsion (T\/D) in juvenile rats. Thirty-two rats were randomized into: (1) the sham group: rats received sham operations with no other interventions; (2) the IDE group: rats received idebenone (100\u00a0mg\/kg, i. p) without T\/D; (3) the T\/D group: rats underwent torsion for 2\u00a0h and detorsion for 4\u00a0h; and (4) the IDE+ T\/D group: rats received IDE 1\u00a0h before T\/D. Testicular malondialdehyde (MDA), total nitrite\/nitrate (NOx), total antioxidant capacity (TAC), tumor necrosis factor-\u03b1 (TNF-\u03b1), caspase-3, sirtuin type 1 (Sirt1), serum interleukin-1\u03b2 (IL-1\u03b2), total cholesterol, and testosterone were measured. Histological changes, nuclear factor (erythroid-derived 2)-like-2 factors (Nrf2), and proliferating cell nuclear antigen (PCNA) immuno-expressions were assessed. T\/D displayed an increase in MDA, NOx, TNF-\u03b1, caspase-3, IL-1\u03b2, and total cholesterol with a significant decrease in TAC, Sirt1, and testosterone and strong positive Nrf2 and negative PCNA immuno-expressions. IDE could improve all oxidative, inflammatory, and apoptotic indicators. Therefore, IDE significantly reduced testicular ischemia-reperfusion injury in the juvenile rat testicular T\/D model by limiting oxidative stress, inflammation, and apoptosis via the Sirt1\/Nrf2\/TNF-\u03b1 pathway.<\/jats:p>","DOI":"10.1177\/09603271221102515","type":"journal-article","created":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T14:10:36Z","timestamp":1653055836000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":26,"title":["Idebenone regulates sirt1\/Nrf2\/TNF-\u03b1 pathway with inhibition of oxidative stress, inflammation, and apoptosis in testicular torsion\/detorsion in juvenile rats"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6511-1797","authenticated-orcid":false,"given":"Walaa Yehia","family":"Abdelzaher","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine Minia University, Minia, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4947-0495","authenticated-orcid":false,"given":"Gomaa","family":"Mostafa-Hedeab","sequence":"additional","affiliation":[{"name":"Pharmacology Department, Medical College, Jouf University, KSA"},{"name":"Pharmacology Department, Faculty of Medicine Beni-Suef University, Beni Suef, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdel Hamid","family":"Sayed AboBakr Ali","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Faculty of Medicine Minia University, Minia, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0456-9021","authenticated-orcid":false,"given":"Michael Atef","family":"Fawzy","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy, Minia University, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira 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