{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:13:33Z","timestamp":1790802813425,"version":"4.1.0"},"reference-count":62,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010090","name":"Women and Children\u2019s Health Research Institute","doi-asserted-by":"publisher","award":["2096"],"award-info":[{"award-number":["2096"]}],"id":[{"id":"10.13039\/100010090","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002948","name":"Hubei University of Technology","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002948","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002428","name":"Fonds zur F\u00f6rderung der wissenschaftlichen Forschung","doi-asserted-by":"crossref","award":["L313-B13"],"award-info":[{"award-number":["L313-B13"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Canadian Foundation for Women\u2019s Health"},{"DOI":"10.13039\/100009326","name":"Cancer Research Society","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100009326","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","award":["CIHR 232514"],"award-info":[{"award-number":["CIHR 232514"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Saudi Cultural Bureau, Ottawa, Canada"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There are hereditary types of nephroblastoma or Wilms\u2019 tumor associated with exposure of the germ cells of either parent to harmful environmental factors. Some studies have examined the exposure of compounds used pesticides and herbicides as a risk factor for Wilms\u2019 tumor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review and meta-analysis were carried out on case-control studies to establish the potential link between exposure to these organic molecules and Wilms\u2019 tumor occurrence in children rigorously. We examined the monographs on some organo-phosphate insecticides and herbicides issued by the International Association for the Research on Cancer (IARC) under the auspices of the World Health Organization (WHO). PUBMED, SCOPUS, and Google Scholar studies (1960\u20132021) were identified and systematically reviewed following Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Subgroup analyses were conducted after stratification for occupational versus residential exposure and before birth (prenatal) vs. after birth (postnatal) exposure. In addition, we revised the monographs on chemical compounds issued recently by the IARC\/WHO.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our findings seem to consolidate that parental pesticide exposure during the preconception or pregnancy period is correlated with an increased occurrence risk for Wilms\u2019 tumor. We confirm the validity of the WHO essays on certain organophosphate herbicides and insecticides, which support these compounds, may be highly relevant in future cancer prevention policies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Parental exposure to pesticides, particularly in household settings, is poorly emphasized in our society. There is a strong association between these organophosphate compounds and pediatric cancer. Public health agencies may need to take stronger action than in the past.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09603271221136211","type":"journal-article","created":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T22:34:46Z","timestamp":1666823686000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Exposure to pesticides and pediatric Wilms\u2019 tumor. A meta-analysis on pre-conception and pregnancy parental exposure with an IARC\/WHO commentary"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1820-7598","authenticated-orcid":false,"given":"A","family":"Khan","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, University of Alberta Hospital, Edmonton, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Feulefack","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, University of Alberta Hospital, Edmonton, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2779-7879","authenticated-orcid":false,"given":"CM","family":"Sergi","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, University of Alberta Hospital, Edmonton, AB, Canada"},{"name":"Department of Pediatrics, Stollery Children\u2019s Hospital, University of Alberta Hospital, Edmonton, AB, Canada"},{"name":"Division of Anatomic Pathology, University of Ottawa, Ottawa, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,10,26]]},"reference":[{"key":"bibr1-09603271221136211","doi-asserted-by":"publisher","DOI":"10.3109\/15513819009067094"},{"key":"bibr2-09603271221136211","volume-title":"Cancer incidence and survival among children and adolescents: United States SEER program 1975-1995","author":"Ries LAG","year":"1999"},{"key":"bibr3-09603271221136211","first-page":"369","volume":"48","author":"Sergi C","year":"2018","journal-title":"Ann Clin Lab Sci"},{"key":"bibr4-09603271221136211","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3016.2010.01133.x"},{"key":"bibr5-09603271221136211","first-page":"429","volume":"68","author":"Breslow NE","year":"1982","journal-title":"J Natl Cancer Inst"},{"key":"bibr6-09603271221136211","first-page":"301","volume":"138","author":"Danglot-Banck C","year":"2002","journal-title":"Gac Med Mex"},{"key":"bibr7-09603271221136211","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1972.tb46675.x"},{"key":"bibr8-09603271221136211","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3016.1994.tb00439.x"},{"key":"bibr9-09603271221136211","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1990.432"},{"key":"bibr10-09603271221136211","first-page":"313","volume":"48","author":"Knudson AG","year":"1972","journal-title":"J Natl Cancer Inst"},{"key":"bibr11-09603271221136211","first-page":"2972","volume":"47","author":"Bunin GR","year":"1987","journal-title":"Cancer Res"},{"key":"bibr12-09603271221136211","doi-asserted-by":"publisher","DOI":"10.1136\/vr.159.1.16"},{"key":"bibr13-09603271221136211","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.epirev.a036201"},{"key":"bibr14-09603271221136211","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a117422"},{"key":"bibr15-09603271221136211","first-page":"14","volume":"1","author":"Chaturvedi M","year":"2013","journal-title":"Res J Chem Env Sci"},{"key":"bibr16-09603271221136211","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.98106893"},{"key":"bibr17-09603271221136211","doi-asserted-by":"publisher","DOI":"10.1080\/10937400601034589"},{"key":"bibr18-09603271221136211","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.971051068"},{"key":"bibr19-09603271221136211","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijheh.2007.03.001"},{"key":"bibr20-09603271221136211","doi-asserted-by":"publisher","DOI":"10.1080\/2331205X.2016.1155373"},{"key":"bibr21-09603271221136211","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0085035"},{"key":"bibr22-09603271221136211","unstructured":"Keith Chen M, Zhuo Y, de la Fuente M, et al. 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