{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:27:01Z","timestamp":1777667221810,"version":"3.51.4"},"reference-count":74,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n                    Oxidative stress appears to possess a central role in CIN pathophysiology. Resveratrol (Res) and lycopene (Lyc) are strong natural antioxidants evaluated in a limited number of CIN animal studies in vivo. The aim of the study was to evaluate the potential renoprotective effects of Res\/Lyc in a CIN rabbit model. Twenty-four adult male New Zealand white rabbits were equally assigned into four groups: control (saline), CIN (intravenous iopromide; 7.5\u00a0g iodine\/kg), Res + CIN (per os Res; 5\u00a0mg\/kg), and Lyc + CIN (per os Lyc; 4\u00a0mg\/kg). Serum Cr (sCr); symmetric\/asymmetric dimethylarginine (SDMA\/ADMA); oxidative stress biomarkers: malondialdehyde; total antioxidant capacity; catalase; glutathione) were evaluated in blood samples at three time points: right after (0\u00a0h); 24\u00a0h; 48\u00a0h after iopromide\/saline administration. CD20\n                    <jats:sup>+<\/jats:sup>\n                    \/CD3\n                    <jats:sup>+<\/jats:sup>\n                    lymphocytes were determined (48\u00a0h). All animals were sacrificed at 48\u00a0h and both kidneys collected. Oxidative stress biomarkers were measured in renal tissue. sCr and SDMA\/ADMA levels increased significantly in CIN compared to all groups. Oxidative stress secondary to CIN in blood\/kidneys was suppressed by Res\/Lyc. B and T lymphocytes decreased significantly in CIN compared to all groups. The present study provides emerging evidence that Res\/Lyc ameliorate CIN by modulating oxidant\/antioxidant balance in blood\/renal tissue and by inhibiting vasoconstriction\/blood cytotoxicity.\n                  <\/jats:p>","DOI":"10.1177\/09603271221145355","type":"journal-article","created":{"date-parts":[[2022,12,24]],"date-time":"2022-12-24T06:26:52Z","timestamp":1671863212000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Resveratrol and lycopene ameliorate contrast-induced nephropathy in a rabbit model"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0535-281X","authenticated-orcid":false,"given":"Eirini","family":"Fragkiadoulaki","sequence":"first","affiliation":[{"name":"Department of Urology, Medical School, University General Hospital of Heraklion, University of Crete, Heraklion, Greece"},{"name":"Department of Forensic Sciences and Toxicology, Medical 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