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Forty adult male rats were orally treated by gavage daily for 28 consecutive days and divided into four groups; control group administered with corn oil, HBC-treated group (16\u00a0mg\/kg b. wt), thymol-treated group (30\u00a0mg\/kg b. wt), and HBC + THY-treated group. The results revealed that HBC exposure caused a significant decrease in the body weight change, organ weights, sperm functional parameters, serum testosterone level with widespread histological abnormalities. Furthermore, HBC-treated rats showed increased in the serum levels of luteinizing hormone (LH) and follicle stimulating hormone (FSH), epididymal and testicular myeloperoxidase activity, tumor necrosis-\u03b1, interleukin-1\u03b2 level and caspase-3 activity, induced oxidative damage as evidenced by elevated malondialdehyde (MDA), reactive oxygen species (RONS) levels and significant reduction in antioxidant enzyme activities and reduced glutathione (GSH). However, co-treatment of THY with HBC alleviated the HBC-induced epididymal and testicular toxicities. Our findings revealed that HBC acts as a reproductive toxicant in rats and thymol could be a potential remedial agent for HBC-induced reproductive toxicity.<\/jats:p>","DOI":"10.1177\/09603271221149201","type":"journal-article","created":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T08:41:55Z","timestamp":1672994515000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Thymol co-administration abrogates hexachlorobenzene-induced reproductive toxicities in male rats"],"prefix":"10.1177","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6763-162X","authenticated-orcid":false,"given":"Abiola S","family":"Tijani","sequence":"first","affiliation":[{"name":"Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1602-394X","authenticated-orcid":false,"given":"Ebenezer O","family":"Farombi","sequence":"additional","affiliation":[{"name":"Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David O","family":"Olori","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Bowen University, Iwo, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,1,6]]},"reference":[{"key":"bibr1-09603271221149201","volume-title":"An Overview of Male Reproductive Toxicants: Facts and Opinions. 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