{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:04:13Z","timestamp":1792807453031,"version":"4.5.0"},"reference-count":40,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The local renin-angiotensin system has been discovered in the eyes; thus, this study evaluates the Azilsartan effect in the retina and optic nerve toxicity induced by Cisplatin in vivo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>Forty-eight male rats were randomly assigned into six groups of 8 animals. Group 1 was healthy control that received 0.5\u00a0mL\/day of 0.5% carboxymethyl cellulose (CMC) orally (PO). Group 2 received a single dose of the 7.0\u00a0mg\/kg CIS intraperitoneally with 0.5\u00a0mL\/day of 0.5% CMC-PO. Groups 3 and 4 received 3.5 and 7.0\u00a0mg\/kg\/day of AZIL-PO, respectively. Groups 5 and 6 received 3.5 and 7.0\u00a0mg\/kg\/day of AZIL-PO, respectively together with a single dose of 7.0\u00a0mg\/kg of CIS-IP. The ocular tissue and serum estimated the TNF-\u03b1, NF-k\u03b2, and Casp-3. A complete blood count was also measured, and the eye was sent for histological examination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The administration of the 3.5\u00a0mg\/kg AZIL significantly ( p &lt; 0.05) reduced the ocular tissue and serum TNF-\u03b1, NF-kB, and Casp-3 levels, when given to CIS treated group, while the 7.0\u00a0mg\/kg AZIL does not. Additionally, azilsartan shows no negative impact on the CBC in rats. Finally, the eye histological examination showed a significant ( p &lt; 0.05) drop in the signs of inflammation and cellular degeneration, particularly after administration of the 3.5\u00a0mg\/kg AZIL to the CIS-treated group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A low dose of AZIL exerts an anti-inflammation and an anti-apoptotic effect through significant suppression of the pro-inflammatory mediators and an apoptotic biomarker by blocking the local angiotensin II type<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09603271231155092","type":"journal-article","created":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T17:32:52Z","timestamp":1679074372000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Azilsartan suppresses the antiapoptotic biomarker and 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