{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:25:16Z","timestamp":1789496716422,"version":"build-2803163510"},"reference-count":22,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Guangdong Medical Science and Technology Research Foundation","award":["No. A2022341"],"award-info":[{"award-number":["No. A2022341"]}]},{"name":"Scientific Research Project of Guangdong Administration of Traditional Chinese Medicine","award":["No.20231323"],"award-info":[{"award-number":["No.20231323"]}]},{"name":"Hospital level project of Foshan Second People's Hospital","award":["No.2022A01"],"award-info":[{"award-number":["No.2022A01"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:p>Peripheral neurotoxicity injury caused by local anesthetics is a common complication of clinical anesthesia. The study of its mechanism is helpful to prevent and treat the neurotoxic injury of local anesthetics. Previous studies on peripheral neurotoxicity injury caused by local anesthetics have mainly focused on in vitro cell experiments. Due to the lack of an animal model of peripheral neurotoxicity damage caused by local anesthetics, there are few in vivo experimental studies regarding this topic. Herein, 1% ropivacaine hydrochloride was injected into the sciatic nerve by direct incision and exposure of the sciatic nerve to create a local anesthetic neurotoxic injury model. The results showed that 1% ropivacaine hydrochloride could reduce the lower limb motor score and mechanical paw withdrawal threshold in mice 48\u00a0hours after injection. Pathological sections showed that 48\u00a0hours after treatment with 1% ropivacaine hydrochloride, the sciatic nerve showed increased axonal edema and degeneration, edema between nerve fiber bundles, increased degeneration of axon and myelin sheath vacuoles, edema of nerve bundle membrane and local degeneration and necrosis, and a large number of inflammatory cells around the nerve adventitia were soaked. The above results show that under open vision, 1% ropivacaine hydrochloride can cause injury to the sciatic nerve after 48\u00a0h of treatment, which can simulate the neurotoxic damage of local anesthetics. This animal model provides a research tool for studying the mechanism of neurotoxic injury caused by local anesthetics.<\/jats:p>","DOI":"10.1177\/09603271231173382","type":"journal-article","created":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T07:16:10Z","timestamp":1682493370000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Establishment of an animal model of sciatic nerve injury induced by local anesthetics"],"prefix":"10.1177","volume":"42","author":[{"given":"Qi","family":"E","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Foshan Perioperative Medical Engineering Technology Research Center, The Second People`s Hospital of Foshan and Affiliated Foshan Hospital of Southern Medical University, Foshan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunlin","family":"Wu","sequence":"additional","affiliation":[{"name":"Graduate School, Guangdong 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