{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T21:08:35Z","timestamp":1793912915064,"version":"4.8.0"},"reference-count":39,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T00:00:00Z","timestamp":1744588800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T00:00:00Z","timestamp":1744588800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Nephrotoxicity and hepatotoxicity are substantial side effects triggered in individuals injected with 5-fluorouracil (5-FU), an anticancer drug. This study aimed to investigate the impact of the natural antioxidant and anti-inflammatory phenolic compound; protocatechuic acid (PCA) on 5-FU-provoked renal and hepatic injury in rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Rats were allocated to 4 groups: control, 5-FU, 5-FU + PCA (50\u00a0mg\/kg), and 5-FU + PCA (100\u00a0mg\/kg). Rats were intraperitoneally injected 5-FU (75\u00a0mg\/kg; once a week for 21\u00a0days. Protocatechuic acid (50 and 100\u00a0mg\/kg\/day; orally) was administered for 3\u00a0weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Rats co-treated with PCA had lower serum kidney and liver function markers than those receiving 5-FU alone. Furthermore, co-treatment with PCA successfully modulated kidney and liver contents of TNF-\u03b1, NF-\u03baB p65, active caspase-1, IL-1\u03b2, p-p38 MAPK, SOD, GSH, Nrf-2, HO-1 and MDA. Moreover, PCA improved histopathological alterations of both kidney and liver tissues.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PCA exerts its hepatoprotective and nephroprotective effects against 5-FU-triggered toxicity through modulation of oxidative stress and inflammatory pathways, particularly via Nrf-2 activation and NF-\u03baB inhibition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09603271251332914","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T19:51:11Z","timestamp":1744660271000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Protocatechuic acid mitigates 5-fluorouracil-triggered renal and hepatic injury in rats"],"prefix":"10.1177","volume":"44","author":[{"given":"Alhomedy M.","family":"Alharbi","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy, Mansoura University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoda E.","family":"Kafl","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Mansoura University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rania R.","family":"Abdelaziz","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Mansoura University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3283-9471","authenticated-orcid":false,"given":"Ghada M.","family":"Suddek","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Mansoura University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,4,14]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/0960327115573597"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/0960327115626583"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19010025"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-002-0404-0"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/137.9.2043"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114510003910"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/952943"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2006.05.004"},{"key":"e_1_3_6_10_2","first-page":"842","article-title":"The effect of protocatechuic acid on ovarian histopathology and reserve in rat ovarian torsion model","volume":"124","author":"Erimsah S","year":"2023","unstructured":"Erimsah S, Cetinkaya A. 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