{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:14:04Z","timestamp":1790741644943,"version":"4.1.0"},"reference-count":29,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Gansu Provincial Science and Technology Plan, Gansu Provincial Natural Science Foundation","award":["23JRRA1455, 24JRRA766"],"award-info":[{"award-number":["23JRRA1455, 24JRRA766"]}]},{"name":"Science and Technology Plan Project of Lanzhou Science and Technology Bureau, Gansu Province","award":["2023-4-11"],"award-info":[{"award-number":["2023-4-11"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dexmedetomidine (DEX) can offer protection to the nervous, urinary and circulatory systems. It can alleviate local oxidative stress, reduce inflammatory responses, inhibite cellular autophagy and decrease apoptosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To explore the potential protection and possible mechanisms of DEX against propofol (PPF)-induced memory impairment in developing rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>The effects of DEX on spatial learning and passive avoidance abilities of rats were evaluated using eight-arm mirror maze and passive avoidance experiments. mRNA levels were detected using RT-qPCR analysis while protein levels were determined using western blot. A network pharmacology approach was used to predict potential targets of DEX against PPF-induced memory impairment. The cell autophagy and apoptosis were detected using commercial kits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>DEX improved the impairment of developing rats on spatial learning and passive avoidance caused by PPF exposure. DEX regulates autophagic activity to inhibit neuronal apoptosis. RAR\u03b1 and Src were potential targets for DEX against memory impairment caused by PPF exposure. DEX upregulated the expression levels of Bdnf, p-CREB\/CREB, p-Akt\/Akt, and p-TrkB\/TrkB proteins.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>DEX may regulate Bdnf\/TrkB and activate the activity of the PI3K\/Akt signaling pathway by targeting RAR\u03b1 and Src, thereby inhibiting excessive autophagy and alleviating memory impairment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09603271251336467","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T03:30:36Z","timestamp":1745897436000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Protective effects of dexmedetomidine against propofol-induced memory impairment in developing rat involved Src and RAR\u03b1"],"prefix":"10.1177","volume":"44","author":[{"given":"Xiaoyan","family":"Xu","sequence":"first","affiliation":[{"name":"The First People\u2019s Hospital of Lanzhou City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1153-5566","authenticated-orcid":false,"given":"Jianmei","family":"Yang","sequence":"additional","affiliation":[{"name":"The First People\u2019s Hospital of Lanzhou City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Jia","sequence":"additional","affiliation":[{"name":"The First People\u2019s Hospital of Lanzhou City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Hu","sequence":"additional","affiliation":[{"name":"The First People\u2019s Hospital of Lanzhou City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiling","family":"Liu","sequence":"additional","affiliation":[{"name":"Gansu Provincial People\u2019s Hospital"},{"name":"Gansu University of Traditional Chinese Medicine (The First Clinical School of Gansu University of Traditional Chinese Medicine)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,4,29]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-022-02338-9"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anclin.2016.04.001"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117359"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/ANA.0000000000000181"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.2c00755"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12294"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-7094(12)70110-1"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/0300060517734460"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.3439"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40360-022-00555-9"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2018.01.014"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000002904"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000475928"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-017-0510-4"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000001730"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064480"},{"key":"e_1_3_6_18_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.997469"},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-022-00564-w"},{"key":"e_1_3_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.11.020"},{"key":"e_1_3_6_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-10619-0"},{"key":"e_1_3_6_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14819"},{"key":"e_1_3_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155438"},{"key":"e_1_3_6_24_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00547.2023"},{"key":"e_1_3_6_25_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242417251"},{"key":"e_1_3_6_26_2","doi-asserted-by":"publisher","DOI":"10.1186\/s41016-019-0162-y"},{"key":"e_1_3_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.06.005"},{"key":"e_1_3_6_28_2","doi-asserted-by":"publisher","DOI":"10.1039\/C7MB00001D"},{"key":"e_1_3_6_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2013.166"},{"key":"e_1_3_6_30_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1110486108"}],"container-title":["Human &amp; 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