{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:44:21Z","timestamp":1777668261926,"version":"3.51.4"},"reference-count":46,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T00:00:00Z","timestamp":1752796800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T00:00:00Z","timestamp":1752796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Students Research Committee, Tabriz University of Medical Science, Tabriz, Iran","award":["70919"],"award-info":[{"award-number":["70919"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Cisplatin (CIS) is a widely used chemotherapeutic agent; however, it is associated with ovarian toxicity.\n                      <jats:italic toggle=\"yes\">Tribulus Terrestris<\/jats:italic>\n                      (TT) is recognized for its antioxidant and anti-inflammatory properties. This study aims to evaluate the effects of TT extract on ovarian tissue damage induced by cisplatin.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Method<\/jats:title>\n                    <jats:p>Twenty-five female BALB\/c mice were divided into five groups (n = 5): Control, CIS (Cisplatin only), CIS + TT100 (100\u00a0mg\/kg TT extract daily + CIS), CIS + TT300 (300\u00a0mg\/kg TT + CIS), and CIS + TT500 (500\u00a0mg\/kg TT daily + CIS). After 15 days, blood samples were collected for hormonal analysis, and ovaries were harvested for histopathological, immunohistochemical, and biochemical assessments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The CIS group exhibited a significant decline in follicle count compared to the control group (P &lt; 0.001). In contrast, the CIS + TT groups showed a notable increase in follicle count (P &lt; 0.05). TT treatment also resulted in significant improvements in antioxidant markers (SOD, CAT) and a reduction in oxidative stress (MDA) compared to the CIS group. Moreover, E2, AMH, and progesterone concentrations were decreased in the CIS group, while these levels were restored in the TT-treated groups (P &lt; 0.001). The expression of inflammatory markers TNF-\u03b1 and IL-1\u03b2 was higher in the CIS group and decreased in the TT-treated groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Tribulus Terrestris<\/jats:italic>\n                      extract effectively mitigates cisplatin-induced ovarian toxicity by enhancing follicular count, improving antioxidant activity, and reducing oxidative stress. TT treatment also elevated AMH and progesterone levels while decreasing inflammatory markers, underscoring its potential as a protective agent against cisplatin-induced ovarian damage.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09603271251353492","type":"journal-article","created":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T07:08:31Z","timestamp":1752822511000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Protective effects of\n                    <i>Tribulus Terrestris<\/i>\n                    extract on cisplatin-induced ovarian damage: Antioxidants and anti-inflammatory insights"],"prefix":"10.1177","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8907-7378","authenticated-orcid":false,"given":"Morteza","family":"Abdi","sequence":"first","affiliation":[{"name":"Tabriz University of Medical Sciences"},{"name":"Tabriz University of Medical Science"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hadi","family":"Karimzadeh","sequence":"additional","affiliation":[{"name":"Tabriz University of Medical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amirreza","family":"Jourabchi","sequence":"additional","affiliation":[{"name":"Tabriz University of Medical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abbas Majdi","family":"Seghinsara","sequence":"additional","affiliation":[{"name":"Tabriz University of Medical Science"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laleh","family":"Khodaie","sequence":"additional","affiliation":[{"name":"Tabriz University of Medical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,7,18]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-62520-3.00003-8"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21207792"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-20-1178"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2022.115323"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.2147\/JEP.S267383"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2022.e10608"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173168"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-020-01888-0"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.22970"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-021-00620-9"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2021.109402"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10101620"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-019-0980-6"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2020.04.019"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-024-01615-5"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/9781119793007.ch3"},{"key":"e_1_3_6_18_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/5758191"},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.4067\/S0717-95022014000200029"},{"key":"e_1_3_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153462"},{"key":"e_1_3_6_21_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0150400"},{"issue":"1","key":"e_1_3_6_22_2","article-title":"Protective Effect of Falcaria vulgaris Extract on Ethanol Induced Gastric Ulcer in Rat","volume":"5","author":"Khazaei M","year":"2006","unstructured":"Khazaei M, Salehi H. 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