{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:35:22Z","timestamp":1792787722943,"version":"4.5.0"},"reference-count":39,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Clinical study of portable remote three-lead synchronous ECG monitoring system in the diagnosis of arrhythmia in remote areas of Gansu Province from the perspective of precise poverty alleviation"},{"name":"Longyuan Youth Innovative and Entrepreneurial Tale"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>This study examined the cardioprotective effects of Pelargonidin-3-O-glucoside (Pg3G) against myocardial infarction induced by isoproterenol (ISO) in male Wistar rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Animals were divided into four groups each groups contain six animals. Group 1 control; Group 2 Pg3G treated control; Group 3 ISO-control; Group 4 Pg3G + ISO treated rats. At the end of the experiment period the animals were sacrificed and collected the serum, heart tissue used for the experimental work.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>According to the network pharmacology analysis, Prostaglandin-endoperoxide Synthase 2 (PTGS2), Matrix metallo proteins \u22129 (MMP-9), and tumour necrosis factor-alpha (TNF-\u03b1) were identified as potential targets among the 97 common targets between Pg3G and myocardial injury. Further, we investigated that prominent cardiac indicator such creatine kinase (CK), CK-MB, cardiac troponin T (cTnT), and cardiac troponin I (cTnI) were not elevated by ISO in the presence of Pg3G administration. Additionally, Pg3G administration decreased the pro-inflammatory cytokines generated by ISO, including as interleukin-6 (IL-6), interleukin-1 beta (IL-1\u03b2), and TNF-\u03b1, suggesting its anti-inflammatory qualities. Additionally, Pg3G increased levels of reduced glutathione (GSH) and restored the activity of important antioxidant enzymes that were depleted by ISO-induced oxidative stress, including glutathione peroxidase (GPx), catalase (CAT), and superoxide dismutase (SOD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Pg3G capacity to reduce ISO-induced inflammatory, fibrotic, and cardiac toxicity markers in myocardial tissue was demonstrated by gene expression investigations. Therefore, Pg3G may be considered for ISO-induced cardiac injury since it provides significant cardioprotection by reducing oxidative stress, inflammation, and fibrosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09603271251369054","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T07:31:07Z","timestamp":1755847867000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Pelargonidin-3-O-glucoside prevents isoproterenol-induced myocardial infarction via modulating cardiac and inflammatory markers expression in experimental rats"],"prefix":"10.1177","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9128-8162","authenticated-orcid":false,"given":"Jianmei","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Shanghai Pudong New Area People\u2019s Hospital, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8640-1762","authenticated-orcid":false,"given":"Xiaoling","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Huai\u00e1n Clinical Medical College of Jiangsu University (Huai\u00e1n Hospital of Huai\u00e1n City), China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5807-9575","authenticated-orcid":false,"given":"Peng","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The Third People\u2019s Hospital of Gansu Province, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,8,22]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(19)30318-3"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-023-03231-w"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2023.1250340"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1039\/C7FO00569E"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17091588"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21091109"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2021.111581"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.1037151"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nucmedbio.2017.12.006"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2013.08.006"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2023.10.010"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2013.03.009"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.2217\/bmm-2017-0110"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu5093646"},{"key":"e_1_3_7_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-021-00863-x"},{"key":"e_1_3_7_17_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.529075"},{"key":"e_1_3_7_18_2","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00029.2013"},{"key":"e_1_3_7_19_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5276130"},{"key":"e_1_3_7_20_2","doi-asserted-by":"publisher","DOI":"10.1586\/17474124.2015.1002086"},{"issue":"5","key":"e_1_3_7_21_2","first-page":"321","article-title":"Molecular mechanisms behind the chemopreventive effects of anthocyanidins","volume":"2004","author":"Hou DX","year":"2004","unstructured":"Hou DX, Fujii M, Terahara N, et al. 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