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Bisphenol A (BPA), a commonly used organic plasticizer, negatively affects sperm parameters, hormonal levels, and fertility. Octreotide (OCT), a somatostatin analog, was originally used to treat acromegaly, carcinoid tumors, vasoactive intestinal peptide-secreting, and growth hormone-secreting tumors. OCT has demonstrated potential therapeutic properties beyond its traditional use in endocrine disorders. We hypothesized that OCT would attenuate BPA-induced testicular damage through its anti-inflammatory, anti-oxidant, and anti-autophagic properties. This study aimed to assess the mechanisms of BPA-induced testicular toxicity and evaluate the ameliorative effects of OCT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty adult male Sprague Dawley (SD) rats were randomly assigned to four equal groups: group1: saline control, group2: dimethyl sulfoxide (DMSO) vehicle, group3: BPA-treated, and group4: BPA + OCT-treated. Treatments were administered for 4\u00a0weeks. Sperm count, testicular weight, serum testosterone, lactate dehydrogenase (LDH), alkaline phosphatase (ALP), total antioxidant capacity (TAC), testicular levels of malondialdehyde (MDA), tumor necrosis factor-alpha (TNF\u03b1), Beclin-1 (BECN-1), Microtubule-associated proteins 1A\/1B light chain 3A (MAP1LC3A\/LC3), mammalian target of rapamycin (M-TOR), histopathological examination, apoptotic index, and Johnson\u2019s score were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>BPA administration significantly impaired spermatogenesis, reduced serum testosterone and TAC, and increased MDA, TNF\u03b1, and autophagy-related markers, along with histopathological damage of testis. Co-treatment with OCT mitigated these effects by improving sperm parameters, hormone levels, oxidative stress markers, inflammatory cytokines, and testicular histology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The findings suggest that OCT exerts a protective effect against BPA-induced testicular toxicity, through its anti-inflammatory, antioxidant, and autophagy-modulating properties. OCT may offer therapeutic potential in mitigating BPA-induced testicular toxicity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09603271251388830","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T11:25:27Z","timestamp":1764156327000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Octreotide ameliorates Bisphenol A-induced testicular toxicity via autophagy-inflammation pathway modulation"],"prefix":"10.1177","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9068-4641","authenticated-orcid":false,"given":"Basma B.","family":"Morad","sequence":"first","affiliation":[{"name":"Tanta University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ola M.","family":"Salem","sequence":"additional","affiliation":[{"name":"Tanta University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasha Osama","family":"El-Esawy","sequence":"additional","affiliation":[{"name":"Tanta University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4210-3399","authenticated-orcid":false,"given":"Fleur F.","family":"Abd Elmonem","sequence":"additional","affiliation":[{"name":"Tanta University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2021.127097"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12940-021-00779-y"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/toxics10050224"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9050405"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2024.108898"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.53730\/ijhs.v6nS6.9754"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aju.2017.11.001"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/genes13071182"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21093289"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/and.14602"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2018.06.004"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.3347\/kjp.2017.55.1.81"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-023-02170-9"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2024.111455"},{"key":"e_1_3_6_16_2","first-page":"6139","article-title":"Octreotide protects doxorubicin-induced cardiac toxicity via regulating oxidative stress","volume":"22","author":"Dai G","year":"2018","unstructured":"Dai G, Wang Z, Zhang J. 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