{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:34:14Z","timestamp":1777667654790,"version":"3.51.4"},"reference-count":8,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1983,4,1]],"date-time":"1983-04-01T00:00:00Z","timestamp":418003200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Toxicology"],"published-print":{"date-parts":[[1983,4]]},"abstract":"<jats:p>1 Out of 493 patients with suspected acute chlormethiazole poisoning notified to the Poisons Unit, Guy's Hospital during 1978-1981, the diagnosis was confirmed either analytically or by detailed clinical information in 108 patients, 40 of whom had ingested chlormethiazole alone.<\/jats:p>\n                  <jats:p>2 The principal signs reported indicate that the clinical features of acute chlormethiazole poisoning resemble those of barbiturate poisoning, with deep coma ( n = 66), respiratory depression ( n = 26) and hypotension ( n = 17) in the severe cases. Five patients died as a result of early, profound respiratory depression.<\/jats:p>\n                  <jats:p>3 In 53 survivors in whom toxicological analyses were performed, poisoning with chlormethiazole alone had a better prognosis than when ethanol or other drugs were also present, except in patients with hepatic or pulmonary disease or in the elderly.<\/jats:p>\n                  <jats:p>4 These results emphasise that although patients poisoned with chlormethiazole who survive to reach hospital generally have a good prognosis, fatal respiratory complications often occur before the patient can be treated.<\/jats:p>","DOI":"10.1177\/096032718300200232","type":"journal-article","created":{"date-parts":[[2008,12,24]],"date-time":"2008-12-24T01:08:04Z","timestamp":1230080884000},"page":"361-369","source":"Crossref","is-referenced-by-count":3,"title":["Acute Chlormethiazole Poisoning in Patients Notified to the Poisons Unit, Guy's Hospital, 1978-1981"],"prefix":"10.1177","volume":"2","author":[{"given":"A.","family":"Houston","sequence":"first","affiliation":[{"name":"Poisons Unit, Guy's Hospital, London SE 1 9RT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.G.","family":"Essex","sequence":"additional","affiliation":[{"name":"Poisons Unit, Guy's Hospital, London SE 1 9RT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.M.","family":"Wiseman","sequence":"additional","affiliation":[{"name":"Poisons Unit, Guy's Hospital, London SE 1 9RT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.J.","family":"Flanagan","sequence":"additional","affiliation":[{"name":"Poisons Unit, Guy's Hospital, London SE 1 9RT"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1983,4,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1039\/an9669100742"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(00)95507-9"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6194.819"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.6114.693"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6195.902-a"},{"key":"atypb6","volume-title":"Treatment of common acute poisonings","author":"Matthew, H.","year":"1979","edition":"4"},{"key":"atypb7","volume-title":"Mortality Statistics: accidents and violence","author":"Office Of Population Censuses And Surveys.","year":"1973"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1177\/000456328201900413"}],"container-title":["Human Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/096032718300200232","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/096032718300200232","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:47:28Z","timestamp":1777448848000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/096032718300200232"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,4]]},"references-count":8,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1983,4]]}},"alternative-id":["10.1177\/096032718300200232"],"URL":"https:\/\/doi.org\/10.1177\/096032718300200232","relation":{},"ISSN":["0144-5952"],"issn-type":[{"value":"0144-5952","type":"print"}],"subject":[],"published":{"date-parts":[[1983,4]]}}}